| pubmed-article:17828272 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17828272 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:17828272 | lifeskim:mentions | umls-concept:C0021368 | lld:lifeskim |
| pubmed-article:17828272 | lifeskim:mentions | umls-concept:C0927232 | lld:lifeskim |
| pubmed-article:17828272 | lifeskim:mentions | umls-concept:C0024264 | lld:lifeskim |
| pubmed-article:17828272 | lifeskim:mentions | umls-concept:C1831732 | lld:lifeskim |
| pubmed-article:17828272 | lifeskim:mentions | umls-concept:C0033414 | lld:lifeskim |
| pubmed-article:17828272 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:17828272 | pubmed:dateCreated | 2007-10-5 | lld:pubmed |
| pubmed-article:17828272 | pubmed:abstractText | T(H)17 lymphocytes appear to be essential in the pathogenesis of numerous inflammatory diseases. We demonstrate here the expression of IL-17 and IL-22 receptors on blood-brain barrier endothelial cells (BBB-ECs) in multiple sclerosis lesions, and show that IL-17 and IL-22 disrupt BBB tight junctions in vitro and in vivo. Furthermore, T(H)17 lymphocytes transmigrate efficiently across BBB-ECs, highly express granzyme B, kill human neurons and promote central nervous system inflammation through CD4+ lymphocyte recruitment. | lld:pubmed |
| pubmed-article:17828272 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17828272 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17828272 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:17828272 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17828272 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:17828272 | pubmed:issn | 1078-8956 | lld:pubmed |
| pubmed-article:17828272 | pubmed:author | pubmed-author:PratAlexandre... | lld:pubmed |
| pubmed-article:17828272 | pubmed:author | pubmed-author:GiulianiFabri... | lld:pubmed |
| pubmed-article:17828272 | pubmed:author | pubmed-author:ArbourNathali... | lld:pubmed |
| pubmed-article:17828272 | pubmed:author | pubmed-author:BecherBurkhar... | lld:pubmed |
| pubmed-article:17828272 | pubmed:author | pubmed-author:IferganIgalI | lld:pubmed |
| pubmed-article:17828272 | pubmed:author | pubmed-author:BernardMoniqu... | lld:pubmed |
| pubmed-article:17828272 | pubmed:author | pubmed-author:KebirHaniaH | lld:pubmed |
| pubmed-article:17828272 | pubmed:author | pubmed-author:KreymborgKath... | lld:pubmed |
| pubmed-article:17828272 | pubmed:author | pubmed-author:CayrolRomainR | lld:pubmed |
| pubmed-article:17828272 | pubmed:author | pubmed-author:Dodelet-Devil... | lld:pubmed |
| pubmed-article:17828272 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17828272 | pubmed:volume | 13 | lld:pubmed |
| pubmed-article:17828272 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17828272 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17828272 | pubmed:pagination | 1173-5 | lld:pubmed |
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| pubmed-article:17828272 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17828272 | pubmed:articleTitle | Human TH17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation. | lld:pubmed |
| pubmed-article:17828272 | pubmed:affiliation | Neuroimmunology Unit, Center for the Study of Brain Diseases, Centre Hospitalier de l'Université de Montréal-Notre-Dame Hospital, 1560 Sherbrooke Street East, Montreal, Quebec H2L 4M1, Canada. | lld:pubmed |
| pubmed-article:17828272 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17828272 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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