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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2007-10-5
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pubmed:abstractText |
T(H)17 lymphocytes appear to be essential in the pathogenesis of numerous inflammatory diseases. We demonstrate here the expression of IL-17 and IL-22 receptors on blood-brain barrier endothelial cells (BBB-ECs) in multiple sclerosis lesions, and show that IL-17 and IL-22 disrupt BBB tight junctions in vitro and in vivo. Furthermore, T(H)17 lymphocytes transmigrate efficiently across BBB-ECs, highly express granzyme B, kill human neurons and promote central nervous system inflammation through CD4+ lymphocyte recruitment.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1078-8956
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
13
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1173-5
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pubmed:meshHeading |
pubmed-meshheading:17828272-Blood-Brain Barrier,
pubmed-meshheading:17828272-CD4-Positive T-Lymphocytes,
pubmed-meshheading:17828272-Case-Control Studies,
pubmed-meshheading:17828272-Cell Membrane Permeability,
pubmed-meshheading:17828272-Cell Movement,
pubmed-meshheading:17828272-Cells, Cultured,
pubmed-meshheading:17828272-Central Nervous System,
pubmed-meshheading:17828272-Dose-Response Relationship, Drug,
pubmed-meshheading:17828272-Endothelial Cells,
pubmed-meshheading:17828272-Endothelium, Vascular,
pubmed-meshheading:17828272-Granzymes,
pubmed-meshheading:17828272-Humans,
pubmed-meshheading:17828272-Inflammation,
pubmed-meshheading:17828272-Interleukin-17,
pubmed-meshheading:17828272-Multiple Sclerosis,
pubmed-meshheading:17828272-Receptors, Interleukin,
pubmed-meshheading:17828272-T-Lymphocytes, Helper-Inducer,
pubmed-meshheading:17828272-Tight Junctions
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pubmed:year |
2007
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pubmed:articleTitle |
Human TH17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation.
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pubmed:affiliation |
Neuroimmunology Unit, Center for the Study of Brain Diseases, Centre Hospitalier de l'Université de Montréal-Notre-Dame Hospital, 1560 Sherbrooke Street East, Montreal, Quebec H2L 4M1, Canada.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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