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rdf:type |
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lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0036667,
umls-concept:C0072899,
umls-concept:C0185117,
umls-concept:C0205148,
umls-concept:C0312418,
umls-concept:C0392747,
umls-concept:C0439825,
umls-concept:C0439831,
umls-concept:C0443172,
umls-concept:C0851285,
umls-concept:C2911684
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pubmed:issue |
10
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pubmed:dateCreated |
2007-9-25
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pubmed:abstractText |
We report a robust regulation of surface AMPA receptors in mouse auditory neurons, both with application of glutamate receptor agonists in cultured neurons and in response to acoustic stimulation in vivo. The reversible reduction of surface AMPA receptors following acoustic stimulation correlated with changes in acoustic sensitivity. Thus we show that AMPA receptor cycling is important for optimizing synaptic transfer at one of the most exacting synapses in the body.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1097-6256
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
10
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1238-40
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pubmed:meshHeading |
pubmed-meshheading:17828255-Acoustic Stimulation,
pubmed-meshheading:17828255-Animals,
pubmed-meshheading:17828255-Animals, Newborn,
pubmed-meshheading:17828255-Auditory Threshold,
pubmed-meshheading:17828255-Dose-Response Relationship, Radiation,
pubmed-meshheading:17828255-Evoked Potentials, Auditory,
pubmed-meshheading:17828255-Excitatory Amino Acid Agonists,
pubmed-meshheading:17828255-Excitatory Amino Acid Antagonists,
pubmed-meshheading:17828255-Gene Expression Regulation,
pubmed-meshheading:17828255-Mice,
pubmed-meshheading:17828255-Neurons, Afferent,
pubmed-meshheading:17828255-Receptors, AMPA,
pubmed-meshheading:17828255-Spiral Ganglion,
pubmed-meshheading:17828255-Time Factors
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pubmed:year |
2007
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pubmed:articleTitle |
Auditory sensitivity regulation via rapid changes in expression of surface AMPA receptors.
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pubmed:affiliation |
Department of Otology and Laryngology, Harvard Medical School, 243 Charles Street, Boston, Massachusetts 02114, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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