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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
1992-3-16
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pubmed:abstractText |
The immunoreactivity of types I, III and V collagen, fibronectin and transforming growth factor-beta (TGF-beta) was studied by an immunogold labeling method in retinal vessels of rats with experimental autoimmune uveoretinitis (EAU) induced by retinal S-antigen. The basal lamina of retinal capillaries in normal rats showed low immunoreactivities for the extracellular matrix components and TGF-beta. However, at the peak of inflammation (day 13-16 postimmunization), labeling of all three types of collagen and fibronectin increased considerably in the basal lamina of retinal vessels. TGF-beta immunoreactivity was detected mainly in the vascular endothelium and the pericytes. The results suggest that TGF-beta synthesized by the endothelial cells and pericytes may regulate the synthesis and composition of extracellular matrix components in the vascular basal lamina during the course of EAU development.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0271-3683
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
10
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1059-63
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:1782804-Animals,
pubmed-meshheading:1782804-Antigens,
pubmed-meshheading:1782804-Arrestin,
pubmed-meshheading:1782804-Autoantigens,
pubmed-meshheading:1782804-Autoimmune Diseases,
pubmed-meshheading:1782804-Collagen,
pubmed-meshheading:1782804-Endothelium, Vascular,
pubmed-meshheading:1782804-Eye Proteins,
pubmed-meshheading:1782804-Female,
pubmed-meshheading:1782804-Fibronectins,
pubmed-meshheading:1782804-Immunohistochemistry,
pubmed-meshheading:1782804-Membrane Proteins,
pubmed-meshheading:1782804-Microscopy, Immunoelectron,
pubmed-meshheading:1782804-Phosphodiesterase Inhibitors,
pubmed-meshheading:1782804-Rats,
pubmed-meshheading:1782804-Rats, Inbred Lew,
pubmed-meshheading:1782804-Retinal Vessels,
pubmed-meshheading:1782804-Retinitis,
pubmed-meshheading:1782804-Transforming Growth Factor beta,
pubmed-meshheading:1782804-Uveitis
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pubmed:year |
1991
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pubmed:articleTitle |
Increased immunoreactivity of collagen types I, III and V, fibronectin and TGF-beta in retinal vessels of rats with experimental autoimmune uveoretinitis.
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pubmed:affiliation |
Kresge Eye Institute, Wayne State University School of Medicine, Detroit, MI.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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