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rdf:type |
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lifeskim:mentions |
umls-concept:C0003232,
umls-concept:C0017258,
umls-concept:C0017262,
umls-concept:C0048207,
umls-concept:C0055940,
umls-concept:C0185117,
umls-concept:C0205349,
umls-concept:C0205431,
umls-concept:C0220781,
umls-concept:C1441547,
umls-concept:C2911684
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pubmed:issue |
8
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pubmed:dateCreated |
2007-9-10
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pubmed:abstractText |
Three new aminocoumarin antibiotics, termed ferulobiocin, 3-chlorocoumarobiocin and 8'-dechloro-3-chlorocoumarobiocin, were isolated from the culture broth of a Streptomyces coelicolor M512 strain expressing a modified clorobiocin biosynthetic gene cluster. Structural analysis showed that these new aminocoumarins were very similar to clorobiocin, with a substituted 4-hydroxycinnamoyl moieties instead of the prenylated 4-hydroxybenzoyl moiety of clorobiocin. The possible biosynthetic origin of these moieties is discussed.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0021-8820
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
60
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
504-10
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pubmed:meshHeading |
pubmed-meshheading:17827661-Aminocoumarins,
pubmed-meshheading:17827661-Anti-Bacterial Agents,
pubmed-meshheading:17827661-Coumaric Acids,
pubmed-meshheading:17827661-Culture Media,
pubmed-meshheading:17827661-Gene Expression,
pubmed-meshheading:17827661-Genes, Bacterial,
pubmed-meshheading:17827661-Microbial Sensitivity Tests,
pubmed-meshheading:17827661-Multigene Family,
pubmed-meshheading:17827661-Novobiocin,
pubmed-meshheading:17827661-Streptomyces coelicolor
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pubmed:year |
2007
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|
pubmed:articleTitle |
New aminocoumarin antibiotics derived from 4-hydroxycinnamic acid are formed after heterologous expression of a modified clorobiocin biosynthetic gene cluster.
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pubmed:affiliation |
Pharmazeutisches Institut, Eberhard-Karls-Universität Tübingen, Auf der Morgenstelle 8, 72076 Tübingen, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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