17827458

Source:http://linkedlifedata.com/resource/pubmed/id/17827458

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0017387, umls-concept:C0042776, umls-concept:C1522449, umls-concept:C1999177
pubmed:issue	26
pubmed:dateCreated	2007-9-10
pubmed:abstractText	Concurrent radiotherapy and chemotherapy have been used to treat a variety of tumors to improve local control and overall survival. Gene therapy strategies represent a novel means to further improve the therapeutic ratio of ionizing radiation. Cancer gene therapy strategies in clinical trials include the use of replication-defective shuttle vectors to deliver exogenous genes and replication-competent oncolytic viruses. This review focuses on these approaches in the context of radiotherapy and radiochemotherapy. In the shuttle vector approach, exogenous gene products that enhance ionizing radiation-mediated tumor cell destruction have been selected. Moreover, the expression of exogenous genes encoding therapeutic proteins can be regulated through the use of ionizing radiation-enhanced promoters. Also, genetically engineered attenuated replication-competent viruses have been investigated in clinical trials. Preclinical data indicate that ionizing radiation interacts with replication-competent oncolytic viruses to enhance viral replication and tumor destruction. Here, we review the background preclinical and current clinical data utilizing gene therapy with radiotherapy.
pubmed:grant	http://linkedlifedata.com/resource/pubmed/grant/P01 CA 71933-07, http://linkedlifedata.com/resource/pubmed/grant/R01 CA 111423
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/8309333
pubmed:citationSubset	IM
pubmed:status	MEDLINE
pubmed:month	Sep
pubmed:issn	1527-7755
pubmed:author	pubmed-author:AdvaniSunil JSJ, pubmed-author:ChmuraSteven JSJ, pubmed-author:WeichselbaumRalph RRR
pubmed:issnType	Electronic
pubmed:day	10
pubmed:volume	25
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	4090-5
pubmed:dateRevised	2007-12-3
pubmed:meshHeading	pubmed-meshheading:17827458-Gene Therapy, pubmed-meshheading:17827458-Humans, pubmed-meshheading:17827458-Neoplasms, pubmed-meshheading:17827458-Viruses
pubmed:year	2007
pubmed:articleTitle	Enhancing radiotherapy with genetically engineered viruses.
pubmed:affiliation	Department of Radiation and Cellular Oncology, Center for Molecular Medicine, University of Chicago, Chicago, IL, USA.
pubmed:publicationType	Journal Article, Review, Research Support, N.I.H., Extramural