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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2007-10-18
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pubmed:abstractText |
Voriconazole, like all other antifungals of the azole group, is potentially hepatotoxic. A large interpatient variability of liver enzyme elevations during oral or intravenous (iv) voriconazole administration is observed. This interpatient variability may be explained by differences in voriconazole metabolism because of cytochrome P450 polymorphisms. We examined the relationship between cytochrome P450 polymorphisms and hepatotoxicity in immunocompromised patients predominantly receiving oral formulations of voriconazole.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0305-7453
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
60
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1104-7
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:17827141-Administration, Oral,
pubmed-meshheading:17827141-Adolescent,
pubmed-meshheading:17827141-Adult,
pubmed-meshheading:17827141-Aged,
pubmed-meshheading:17827141-Aged, 80 and over,
pubmed-meshheading:17827141-Antifungal Agents,
pubmed-meshheading:17827141-Cytochrome P-450 Enzyme System,
pubmed-meshheading:17827141-Drug-Induced Liver Injury,
pubmed-meshheading:17827141-Female,
pubmed-meshheading:17827141-Genetic Predisposition to Disease,
pubmed-meshheading:17827141-Humans,
pubmed-meshheading:17827141-Injections, Intravenous,
pubmed-meshheading:17827141-Liver,
pubmed-meshheading:17827141-Male,
pubmed-meshheading:17827141-Middle Aged,
pubmed-meshheading:17827141-Polymorphism, Genetic,
pubmed-meshheading:17827141-Pyrimidines,
pubmed-meshheading:17827141-Retrospective Studies,
pubmed-meshheading:17827141-Triazoles
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pubmed:year |
2007
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pubmed:articleTitle |
Hepatotoxicity of oral and intravenous voriconazole in relation to cytochrome P450 polymorphisms.
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pubmed:affiliation |
Department of Internal Medicine, Albert Schweitzer Hospital, Dordrecht, The Netherlands. levin@xs4all.nl
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pubmed:publicationType |
Journal Article
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