Linked Life Data

17825441

Source:http://linkedlifedata.com/resource/pubmed/id/17825441

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2007-11-20
pubmed:abstractText
Serotonin is involved in a wide range of physiological and patho-physiological mechanisms. In particular, 5-HT1A receptors are proposed to mediate stress-adaptation. The aim of this research was to investigate in adolescent rats: first, the consequences of perinatal exposure to 5-metoxytryptamine (5MT), a 5-HT1/5-HT2 serotonergic agonist, on behavioural-stress reactivity in elevated plus maze, open field and forced swim tests; secondly, whether the behavioural effects induced by perinatal exposure to 5MT on open field and forced swim tests were affected by the selective 5-HT1A receptor agonist LY 228729, a compound able to elicit a characteristic set of motor behaviours on these experimental models, and by the co-administration of the selective and silent 5-HT1A antagonist WAY 100635. Results indicate that a single daily injection of 5MT to, pregnant dams from gestational days 12 to 21 (1mg/kg s.c.), and to the pups from postnatal days 2 to 18 (0.5mg kg s.c.), induce in the adolescent rat offspring: an increase in the percentage of entries and time spent on the open arms in the elevated plus maze; a reduction in locomotor activity and rearing frequency, and an increase in the time spent on the central areas in the open field test; a decrease in immobility and an increase in swimming in the forced swim test. Acute administration of LY 228729 (1.5mg/kg s.c.) strongly decreases rearing frequency and increases peripheral activity in the open field test, and decreases immobility and increases swimming in the forced swim test both in perinatally vehicle and 5MT-exposed offspring. Co-administration of WAY 100635 (0.25mg/kg s.c.) abolishes the effects exerted by LY 228729. These results suggest that, in the adolescent rat, perinatal exposure to 5MT enhances the stress-related adaptive behavioural responses, presumably through a predominant action on presynaptic 5-HT1A receptors and does not deteriorate the functional response of 5-HT1A receptors to selective agonist and antagonist compounds.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0166-4328
pubmed:author
pubmed:issnType
Print
pubmed:day
10
pubmed:volume
186
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
98-106
pubmed:meshHeading
pubmed-meshheading:17825441-5-Methoxytryptamine, pubmed-meshheading:17825441-Analysis of Variance, pubmed-meshheading:17825441-Animals, pubmed-meshheading:17825441-Animals, Newborn, pubmed-meshheading:17825441-Anxiety, pubmed-meshheading:17825441-Brain, pubmed-meshheading:17825441-Drug Synergism, pubmed-meshheading:17825441-Ergolines, pubmed-meshheading:17825441-Exploratory Behavior, pubmed-meshheading:17825441-Female, pubmed-meshheading:17825441-Male, pubmed-meshheading:17825441-Motor Activity, pubmed-meshheading:17825441-Piperazines, pubmed-meshheading:17825441-Pregnancy, pubmed-meshheading:17825441-Prenatal Exposure Delayed Effects, pubmed-meshheading:17825441-Presynaptic Terminals, pubmed-meshheading:17825441-Pyridines, pubmed-meshheading:17825441-Rats, pubmed-meshheading:17825441-Rats, Wistar, pubmed-meshheading:17825441-Receptor, Serotonin, 5-HT1A, pubmed-meshheading:17825441-Serotonin Agents, pubmed-meshheading:17825441-Sex Factors, pubmed-meshheading:17825441-Statistics, Nonparametric, pubmed-meshheading:17825441-Stress, Psychological, pubmed-meshheading:17825441-Synapses
pubmed:year
2008
pubmed:articleTitle
Perinatal exposure to 5-methoxytryptamine, behavioural-stress reactivity and functional response of 5-HT1A receptors in the adolescent rat.
pubmed:affiliation
Dipartimento di Scienze Farmacologiche, Università di Palermo, V. Vespro 129, 90127 Palermo, Italy. psyco@unipa.it
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't