Linked Life Data

17825025

Source:http://linkedlifedata.com/resource/pubmed/id/17825025

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2007-9-10
pubmed:abstractText
Statistical validation of a surrogate marker has been studied for more than a decade. Recently, Alonso et al. (2004, Biometrics 60, 724-728) proposed a quantity called the likelihood reduction factor (LRF) to evaluate the validity of a surrogate marker. However, as pointed out in the present article, the LRF may not correctly validate a surrogate marker. Therefore, a new quantity, the proportion of information gain (PIG) using the Kullback-Leibler information, is proposed. Simulations show that under some model assumptions, the PIG precisely reflects the role of a surrogate marker.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0006-341X
pubmed:author
pubmed:issnType
Print
pubmed:volume
63
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
958-62; author reply 962-3
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Quantifying the effect of the surrogate marker by information gain.
pubmed:affiliation
Eli Lilly and Company, Indianapolis, Indiana 46285, USA. qu_yongming@lilly.com
pubmed:publicationType
Journal Article, Comment