Linked Life Data

17824174

Source:http://linkedlifedata.com/resource/pubmed/id/17824174

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2007-9-10
pubmed:abstractText
Rheumatoid arthritis is a chronic disabling disease affecting at least 1% of the population on a worldwide basis. Research aimed at understanding the pathogenesis of this disease led to the identification of TNFalpha as a major pro-inflammatory cytokine expressed in the inflamed joints of patients with rheumatoid arthritis. Subsequently, in vitro studies provided evidence to suggest that TNFalpha played an important role in driving the expression of additional pro-inflammatory cytokines, such as IL-1, GM-CSF, IL-6, and IL-8, in synovial cell cultures. Another important finding that confirmed the pathological significance of TNFalpha was that mice genetically engineered to overexpress TNFalpha spontaneously developed arthritis. Subsequently, the therapeutic effect TNFalpha blockade was tested in animal models prior to clinical trials in human patients, which provided unequivocal verification of the validity of TNFalpha as a therapeutic target. Anti-TNFalpha therapy is now accepted as a fully-validated treatment modality for rheumatoid arthritis.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:author
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
107-30
pubmed:dateRevised
2008-5-21
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
Pathogenesis and therapy of rheumatoid arthritis.
pubmed:affiliation
Kennedy Institute of Rheumatology Division, Imperial College London, 1 Aspenlea Road, W6 8LH London, UK. richard.o.williams@imperial.ac.uk
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't