Linked Life Data

17822130

Source:http://linkedlifedata.com/resource/pubmed/id/17822130

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
15
pubmed:dateCreated
2007-9-7
pubmed:abstractText
It is widely accepted that the use of total metal concentrations in soil overestimates metal risk from human ingestion of contaminated soils. In vitro simulators have been used to estimate the fraction of arsenic present in soil that is bioaccessible in the human digestive track. These approaches assume that the bioaccessible fraction remains constant across soil total metal concentrations and that intestinal microbiota do not contribute to arsenic release. Here, we evaluate both of these assumptions in two size fractions (bulk and <38 microm) of arsenic-rich mine tailings from the Goldenville, Lower Seal Harbour, and Montague Gold Districts, Nova Scotia. These samples were evaluated using an in vitro gastrointestinal model, the Simulator of the Human Intestinal Ecosystem (SHIME). Arsenic bioaccessibility, which ranged between 2 and 20% in the small intestine and 4 and 70% in the colon, was inversely related to total arsenic concentration in the mine tailings. Additionally, arsenic bioaccessibility was greater in the bulk fraction than in the <38 microm fraction in the small intestine and colon while colon microbes increased the bioaccessibility of arsenic in mine tailings. These results suggest that the practice of using a constant percent arsenic bioaccessibility across all metal concentrations in risk assessment should be revisited.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0013-936X
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
41
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
5542-7
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Gastrointestinal microbes increase arsenic bioaccessibility of ingested mine tailings using the simulator of the human intestinal microbial ecosystem.
pubmed:affiliation
Graduate Program in Toxicology, University of Saskatchewan, Saskatoon, SK, Canada.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't