Linked Life Data

1781930

Source:http://linkedlifedata.com/resource/pubmed/id/1781930

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1992-3-17
pubmed:abstractText
Experiments were performed to investigate the change of hepatic T4 5'-deiodination and the preventive effects of selenium (Se) and vitamin E in rats fed grains from a Keshan disease (KD) endemic area. The results showed that consumption of the endemic grain for 8 weeks caused a significant reduction in hepatic T4 5'-monodeiodinase and glutathione peroxidase activities, and a marked enhancement of hepatic malondialdehyde content. These changes could be effectively prevented through Se or vitamin E supplementation to the diet. These observations confirm the reduced ability of hepatic T4 5'-deiodination induced by the pathogenic factors existing in the endemic grains, and the preventive effects of selenium and vitamin E on the alterations. The present study suggests that the reduction in hepatic T4 deiodination in these animals may be the consequence of hepatic damage owing to uncontrolled free radical metabolism, and that the relative deficiency of vitamin E, besides selenium deficiency, may also play a role in the pathogenesis of KD.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0895-3988
pubmed:author
pubmed:issnType
Print
pubmed:volume
4
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
359-65
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
Damage to hepatic thyroxine 5'-deiodination induced by pathogenic factors of Keshan disease and the preventive effects of selenium and vitamin E.
pubmed:affiliation
Institute of Endemic Diseases, Norman Bethune University of Medical Sciences Changchun, Jilin, People's Republic of China.
pubmed:publicationType
Journal Article