Source:http://linkedlifedata.com/resource/pubmed/id/17805195
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
2007-11-30
|
| pubmed:abstractText |
The intent of this study was to assess whether the effect of birth weight on later body composition is modified by Pro12Pro, Pro12Ala, and Ala12Ala genotypes of the peroxisome proliferator-activated receptor gamma-2 (PPARgamma-2) gene. The PPARgamma-2 gene polymorphism was genotyped in 273 adolescents aged 13-18.5 y, born at term and whose birth weight was known. They were selected from a cross-sectional multicenter study conducted in five Spanish cities in 2000-2002. Body mass index (BMI) was calculated from weight and height measurements, and body composition and fat distribution were estimated from skinfold thickness. A total of 229 subjects (111 males and 118 females) carried the Pro12Pro genotype and 44 (22 males and 22 females) the Pro12Ala and Ala12Ala PPARgamma-2 genotypes. In the Pro12Pro group, birth weight Z score was positively associated with both fat-free mass (FFM) (p < 0.05) and fat mass (FM) (p < 0.05), but these relationships disappeared after controlling for age, gestational age, socioeconomic status (SES), physical activity, Tanner stage, sex, and BMI. In the Ala12 group, birth weight Z score was positively associated with FFM (p < 0.01), and this relationship remained significant after controlling for confounding variables (p < 0.05). Small body weight at birth may program lower FFM in adolescents carrying the Ala12 allele in the PPARgamma-2 gene.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Nov
|
| pubmed:issn |
0031-3998
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| pubmed:author |
pubmed-author:AVENA Study Group,
pubmed-author:BuenoGloriaG,
pubmed-author:BuenoManuelM,
pubmed-author:GaragorriJesús MJM,
pubmed-author:García-FuentesMiguelM,
pubmed-author:González-LamuñoDomingoD,
pubmed-author:LabayenIdoiaI,
pubmed-author:MartínezJ AlfredoJA,
pubmed-author:MartiAmeliaA,
pubmed-author:MorenoLuis ALA,
pubmed-author:NovaEstherE,
pubmed-author:OrtegaFrancisco BFB,
pubmed-author:RuizJonatan RJR,
pubmed-author:WärnbergJuliaJ
|
| pubmed:issnType |
Print
|
| pubmed:volume |
62
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
615-9
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| pubmed:meshHeading |
pubmed-meshheading:17805195-Adolescent,
pubmed-meshheading:17805195-Alanine,
pubmed-meshheading:17805195-Birth Weight,
pubmed-meshheading:17805195-Body Composition,
pubmed-meshheading:17805195-Body Fat Distribution,
pubmed-meshheading:17805195-Body Height,
pubmed-meshheading:17805195-Body Mass Index,
pubmed-meshheading:17805195-Body Weight,
pubmed-meshheading:17805195-Cross-Sectional Studies,
pubmed-meshheading:17805195-Female,
pubmed-meshheading:17805195-Gene Frequency,
pubmed-meshheading:17805195-Genotype,
pubmed-meshheading:17805195-Humans,
pubmed-meshheading:17805195-Male,
pubmed-meshheading:17805195-PPAR gamma,
pubmed-meshheading:17805195-Proline,
pubmed-meshheading:17805195-Skinfold Thickness,
pubmed-meshheading:17805195-Spain
|
| pubmed:year |
2007
|
| pubmed:articleTitle |
Effect of the Ala12 allele in the PPARgamma-2 gene on the relationship between birth weight and body composition in adolescents: the AVENA study.
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| pubmed:affiliation |
Department of Nutrition and Food Science, University of the Basque Country, 01006 Vitoria, Spain. idoya.labayen@ehu.es
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Multicenter Study
|