Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2007-9-5
pubmed:abstractText
Gastrodia elata Blume (GEB) is an important medicinal plant in Korea. In order to confirm the anti-tumor activities of GEB extracts, we carried out various in vitro anti-tumor assays, including a wound assay and an invasion assay using an ethyl ether extract of GEB. The results showed that the GEB extract exhibits potent anti-tumor activity in vitro in a dose-dependent manner. The expression of CD44, cdc42, Timp-2 or RhoA mRNA did not change by GEB treatment, compared to that of the control. GTP-Ras, an active form of a G-coupled protein family, however, is associated with the anti-tumor activity of GEB extracts. We examined various molecular markers related to metastasis by reverse transcriptase-polymerase chain reaction with the extract of GEB-treated B16 cells. There was an increase in GTP-Ras expression by the Gastrodia elata Blume extract. Together, these results suggest that the Gastrodia elata Blume extract could have potential in alleviating tumorigenesis, by a GTP-Ras-dependent pathway; although the precise molecular mechanisms are still being examined.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD44, http://linkedlifedata.com/resource/pubmed/chemical/Collagen, http://linkedlifedata.com/resource/pubmed/chemical/Drug Combinations, http://linkedlifedata.com/resource/pubmed/chemical/Laminin, http://linkedlifedata.com/resource/pubmed/chemical/Plant Extracts, http://linkedlifedata.com/resource/pubmed/chemical/Proteoglycans, http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger, http://linkedlifedata.com/resource/pubmed/chemical/Tissue Inhibitor of..., http://linkedlifedata.com/resource/pubmed/chemical/cdc42 GTP-Binding Protein, http://linkedlifedata.com/resource/pubmed/chemical/matrigel, http://linkedlifedata.com/resource/pubmed/chemical/ras Proteins, http://linkedlifedata.com/resource/pubmed/chemical/rhoA GTP-Binding Protein
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1021-335X
pubmed:author
pubmed:issnType
Print
pubmed:volume
18
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
849-53
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed-meshheading:17786345-Animals, pubmed-meshheading:17786345-Antigens, CD44, pubmed-meshheading:17786345-Cells, Cultured, pubmed-meshheading:17786345-Collagen, pubmed-meshheading:17786345-Drug Combinations, pubmed-meshheading:17786345-Endothelium, Vascular, pubmed-meshheading:17786345-Gastrodia, pubmed-meshheading:17786345-Laminin, pubmed-meshheading:17786345-Medicine, East Asian Traditional, pubmed-meshheading:17786345-Melanoma, Experimental, pubmed-meshheading:17786345-Mice, pubmed-meshheading:17786345-Neoplasm Invasiveness, pubmed-meshheading:17786345-Phytotherapy, pubmed-meshheading:17786345-Plant Extracts, pubmed-meshheading:17786345-Proteoglycans, pubmed-meshheading:17786345-RNA, Messenger, pubmed-meshheading:17786345-Reverse Transcriptase Polymerase Chain Reaction, pubmed-meshheading:17786345-Signal Transduction, pubmed-meshheading:17786345-Tissue Inhibitor of Metalloproteinase-2, pubmed-meshheading:17786345-Umbilical Veins, pubmed-meshheading:17786345-Wound Healing, pubmed-meshheading:17786345-cdc42 GTP-Binding Protein, pubmed-meshheading:17786345-ras Proteins, pubmed-meshheading:17786345-rhoA GTP-Binding Protein
pubmed:year
2007
pubmed:articleTitle
Anti-tumor activity of Gastrodia elata Blume is closely associated with a GTP-Ras-dependent pathway.
pubmed:affiliation
Food and Bio-industry Research Institute, Graduate School, Kyungpook National University, Daegu 702-701, Korea.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't