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| pubmed-article:17785777 | lifeskim:mentions | umls-concept:C0086282 | lld:lifeskim |
| pubmed-article:17785777 | lifeskim:mentions | umls-concept:C0332307 | lld:lifeskim |
| pubmed-article:17785777 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:17785777 | lifeskim:mentions | umls-concept:C0021747 | lld:lifeskim |
| pubmed-article:17785777 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:17785777 | lifeskim:mentions | umls-concept:C1415900 | lld:lifeskim |
| pubmed-article:17785777 | lifeskim:mentions | umls-concept:C1521761 | lld:lifeskim |
| pubmed-article:17785777 | lifeskim:mentions | umls-concept:C0220905 | lld:lifeskim |
| pubmed-article:17785777 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:17785777 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:17785777 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:17785777 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:17785777 | pubmed:dateCreated | 2007-9-5 | lld:pubmed |
| pubmed-article:17785777 | pubmed:abstractText | Virus replication induces the expression of antiviral type I (IFN-alphabeta) and type III (IFN-lambda1-3 or IL-28A/B and IL-29) IFN genes via TLR-dependent and -independent pathways. Although type III IFNs differ genetically from type I IFNs, their similar biological antiviral functions suggest that their expression is regulated in a similar fashion. Structural and functional characterization of the IFN-lambda1 and IFN-lambda3 gene promoters revealed them to be similar to IFN-beta and IFN-alpha genes, respectively. Both of these promoters had functional IFN-stimulated response element and NF-kappaB binding sites. The binding of IFN regulatory factors (IRF) to type III IFN promoter IFN-stimulated response element sites was the most important event regulating the expression of these genes. Ectopic expression of the components of TLR7 (MyD88 plus IRF1/IRF7), TLR3 (Toll/IL-1R domain-containing adapter-inducing factor), or retinoic acid-inducible gene I (RIG-I) signal transduction pathways induced the activation of IFN-lambda1 promoter, whereas the IFN-lambda3 promoter was efficiently activated only by overexpression of MyD88 and IRF7. The ectopic expression of Pin1, a recently identified suppressor for IRF3-dependent antiviral response, decreased the IFN promoter activation induced by any of these three signal transduction pathways, including the MyD88-dependent one. To conclude, the data suggest that the IFN-lambda1 gene is regulated by virus-activated IRF3 and IRF7, thus resembling that of the IFN-beta gene, whereas IFN-lambda2/3 gene expression is mainly controlled by IRF7, thus resembling those of IFN-alpha genes. | lld:pubmed |
| pubmed-article:17785777 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17785777 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17785777 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17785777 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:17785777 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17785777 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:17785777 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:17785777 | pubmed:author | pubmed-author:KotenkoSergei... | lld:pubmed |
| pubmed-article:17785777 | pubmed:author | pubmed-author:JulkunenIlkka... | lld:pubmed |
| pubmed-article:17785777 | pubmed:author | pubmed-author:VeckmanVilleV | lld:pubmed |
| pubmed-article:17785777 | pubmed:author | pubmed-author:PietiläTaija... | lld:pubmed |
| pubmed-article:17785777 | pubmed:author | pubmed-author:OsterlundPame... | lld:pubmed |
| pubmed-article:17785777 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17785777 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:17785777 | pubmed:volume | 179 | lld:pubmed |
| pubmed-article:17785777 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17785777 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17785777 | pubmed:pagination | 3434-42 | lld:pubmed |
| pubmed-article:17785777 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:17785777 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17785777 | pubmed:articleTitle | IFN regulatory factor family members differentially regulate the expression of type III IFN (IFN-lambda) genes. | lld:pubmed |
| pubmed-article:17785777 | pubmed:affiliation | Department of Viral Diseases and Immunology, National Public Health Institute, Helsinki, Finland. pamela.osterlund@ktl.fi | lld:pubmed |
| pubmed-article:17785777 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17785777 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:17785777 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:17785777 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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