Linked Life Data

17785777

Source:http://linkedlifedata.com/resource/pubmed/id/17785777

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2007-9-5
pubmed:abstractText
Virus replication induces the expression of antiviral type I (IFN-alphabeta) and type III (IFN-lambda1-3 or IL-28A/B and IL-29) IFN genes via TLR-dependent and -independent pathways. Although type III IFNs differ genetically from type I IFNs, their similar biological antiviral functions suggest that their expression is regulated in a similar fashion. Structural and functional characterization of the IFN-lambda1 and IFN-lambda3 gene promoters revealed them to be similar to IFN-beta and IFN-alpha genes, respectively. Both of these promoters had functional IFN-stimulated response element and NF-kappaB binding sites. The binding of IFN regulatory factors (IRF) to type III IFN promoter IFN-stimulated response element sites was the most important event regulating the expression of these genes. Ectopic expression of the components of TLR7 (MyD88 plus IRF1/IRF7), TLR3 (Toll/IL-1R domain-containing adapter-inducing factor), or retinoic acid-inducible gene I (RIG-I) signal transduction pathways induced the activation of IFN-lambda1 promoter, whereas the IFN-lambda3 promoter was efficiently activated only by overexpression of MyD88 and IRF7. The ectopic expression of Pin1, a recently identified suppressor for IRF3-dependent antiviral response, decreased the IFN promoter activation induced by any of these three signal transduction pathways, including the MyD88-dependent one. To conclude, the data suggest that the IFN-lambda1 gene is regulated by virus-activated IRF3 and IRF7, thus resembling that of the IFN-beta gene, whereas IFN-lambda2/3 gene expression is mainly controlled by IRF7, thus resembling those of IFN-alpha genes.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0022-1767
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
179
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3434-42
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed-meshheading:17785777-Base Sequence, pubmed-meshheading:17785777-Binding Sites, pubmed-meshheading:17785777-Cell Line, pubmed-meshheading:17785777-Cytokines, pubmed-meshheading:17785777-Dendritic Cells, pubmed-meshheading:17785777-Gene Expression Regulation, pubmed-meshheading:17785777-Gene Expression Regulation, Viral, pubmed-meshheading:17785777-Humans, pubmed-meshheading:17785777-Interferon Regulatory Factor-3, pubmed-meshheading:17785777-Interferon Regulatory Factor-7, pubmed-meshheading:17785777-Interferon Type I, pubmed-meshheading:17785777-Interleukins, pubmed-meshheading:17785777-Molecular Sequence Data, pubmed-meshheading:17785777-Multigene Family, pubmed-meshheading:17785777-NF-kappa B, pubmed-meshheading:17785777-Promoter Regions, Genetic, pubmed-meshheading:17785777-Protein Structure, Tertiary, pubmed-meshheading:17785777-Response Elements, pubmed-meshheading:17785777-Sindbis Virus
pubmed:year
2007
pubmed:articleTitle
IFN regulatory factor family members differentially regulate the expression of type III IFN (IFN-lambda) genes.
pubmed:affiliation
Department of Viral Diseases and Immunology, National Public Health Institute, Helsinki, Finland. pamela.osterlund@ktl.fi
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural