|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
17
|
|
pubmed:dateCreated |
2007-9-5
|
|
pubmed:abstractText |
New treatment strategies aimed at damaging tumor vasculature could potentially improve tumor response to radiation therapy. We recently showed that anionic phospholipids, principally phosphatidylserine, are specifically exposed on the luminal surface of tumor blood vessels. Here we tested the hypothesis that radiation therapy can increase phosphatidylserine exposure on lung tumor vasculature, thereby enhancing the antitumor properties of the anti-phosphatidylserine antibody 2aG4.
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|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Sep
|
|
pubmed:issn |
1078-0432
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
1
|
|
pubmed:volume |
13
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
5211-8
|
|
pubmed:dateRevised |
2010-3-23
|
|
pubmed:meshHeading |
pubmed-meshheading:17785577-Animals,
pubmed-meshheading:17785577-Antibodies, Monoclonal,
pubmed-meshheading:17785577-Antibody-Dependent Cell Cytotoxicity,
pubmed-meshheading:17785577-Combined Modality Therapy,
pubmed-meshheading:17785577-Endothelial Cells,
pubmed-meshheading:17785577-Humans,
pubmed-meshheading:17785577-Lung Neoplasms,
pubmed-meshheading:17785577-Macrophages,
pubmed-meshheading:17785577-Male,
pubmed-meshheading:17785577-Mice,
pubmed-meshheading:17785577-Mice, SCID,
pubmed-meshheading:17785577-Monocytes,
pubmed-meshheading:17785577-Neoplasm Transplantation,
pubmed-meshheading:17785577-Phosphatidylserines,
pubmed-meshheading:17785577-Transplantation, Heterologous
|
|
pubmed:year |
2007
|
|
pubmed:articleTitle |
Radiation-enhanced vascular targeting of human lung cancers in mice with a monoclonal antibody that binds anionic phospholipids.
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|
pubmed:affiliation |
Simmons Comprehensive Cancer Center, Hamon Center for Therapeutic Oncology Research, the University of Texas Southwestern Medical Center, Dallas, Texas 75390-9041, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
