Linked Life Data

17785304

Source:http://linkedlifedata.com/resource/pubmed/id/17785304

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2007-9-5
pubmed:abstractText
Screening a cDNA expression library is a powerful technique that allows identification of previously uncharacterized antigens. Proteins recognized by antibodies from patients with autoimmune diseases have been intensively studied over the past two decades since cDNAs encoding autoantigens have become available. Identity of many of them has been defined, and specific structural motifs or post-translational modifications, which may be important to explain the generation of such antibodies during the autoimmune process, have been pointed out. The screening of human umbilical artery or microvascular endothelial cell expression libraries appears to be a useful tool for the characterization of endothelial autoantigens allowing us to identify several molecules recognized from serum anti-endothelial cell antibodies of patients with diseases characterized by immune-mediated endothelial dysfunctions.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0077-8923
pubmed:author
pubmed:issnType
Print
pubmed:volume
1109
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
178-84
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Screening of endothelial expression libraries for the identification of novel autoantigens involved in distinct autoimmune diseases characterized by endothelial dysfunction.
pubmed:affiliation
Dipartimento di Malattie Infettive, Parassitarie e Immunomediate, Istituto Superiore di Sanità, Rome, Italy.
pubmed:publicationType
Journal Article