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rdf:type |
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lifeskim:mentions |
umls-concept:C0001737,
umls-concept:C0019704,
umls-concept:C0681850,
umls-concept:C0871261,
umls-concept:C1550501,
umls-concept:C1704632,
umls-concept:C1706203,
umls-concept:C1706817,
umls-concept:C1707877,
umls-concept:C2349001,
umls-concept:C2697811,
umls-concept:C2911692
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pubmed:issue |
8
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pubmed:dateCreated |
1992-3-9
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pubmed:abstractText |
We compared 1616 sera from HIV-1-infected subjects and matched HIV-negative local controls in Uganda, Kenya and the UK. Sera were screened for specific antibody to HIV-1 p24 Gag and gp120 Env proteins and for p24 antigenaemia. In contrast to the UK, the majority of African HIV-1-infected subjects maintained detectable anti-p24 antibodies. However, lower reactivity of anti-p24 was observed in African AIDS patients, compared with those with asymptomatic HIV-1 infection. This reduction in anti-p24 reactivity with more advanced clinical stage was less marked in African HIV-1 infection than in the UK. Correspondingly, p24 antigenaemia was more common in patients with AIDS from the UK than in African patients (65 versus 4%). Reductions in anti-gp120 reactivity were observed in African AIDS patients, compared with the asymptomatic group. However, median reactivity of anti-gp120 in UK patients remained unchanged in both asymptomatic and AIDS subjects. The differences in humoral response to p24 and gp120 between Africa and the UK are semi-quantitative rather than qualitative and could be explained by initial higher antibody response to HIV-1 in African subjects.
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pubmed:grant |
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pubmed:keyword |
http://linkedlifedata.com/resource/pubmed/keyword/Acquired Immunodeficiency Syndrome,
http://linkedlifedata.com/resource/pubmed/keyword/Africa,
http://linkedlifedata.com/resource/pubmed/keyword/Africa South Of The Sahara,
http://linkedlifedata.com/resource/pubmed/keyword/Biology,
http://linkedlifedata.com/resource/pubmed/keyword/Case Control Studies,
http://linkedlifedata.com/resource/pubmed/keyword/Comparative Studies,
http://linkedlifedata.com/resource/pubmed/keyword/Developed Countries,
http://linkedlifedata.com/resource/pubmed/keyword/Developing Countries,
http://linkedlifedata.com/resource/pubmed/keyword/Diseases,
http://linkedlifedata.com/resource/pubmed/keyword/Eastern Africa,
http://linkedlifedata.com/resource/pubmed/keyword/English Speaking Africa,
http://linkedlifedata.com/resource/pubmed/keyword/Europe,
http://linkedlifedata.com/resource/pubmed/keyword/Examinations And Diagnoses,
http://linkedlifedata.com/resource/pubmed/keyword/Hiv Infections,
http://linkedlifedata.com/resource/pubmed/keyword/IMMUNITY,
http://linkedlifedata.com/resource/pubmed/keyword/Immunologic Factors,
http://linkedlifedata.com/resource/pubmed/keyword/Kenya,
http://linkedlifedata.com/resource/pubmed/keyword/Laboratory Examinations And Diagnoses,
http://linkedlifedata.com/resource/pubmed/keyword/Northern Europe,
http://linkedlifedata.com/resource/pubmed/keyword/Physiology,
http://linkedlifedata.com/resource/pubmed/keyword/Research Methodology,
http://linkedlifedata.com/resource/pubmed/keyword/Studies,
http://linkedlifedata.com/resource/pubmed/keyword/United Kingdom,
http://linkedlifedata.com/resource/pubmed/keyword/Viral Diseases
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0269-9370
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
5
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pubmed:owner |
NLM
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pubmed:authorsComplete |
N
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pubmed:pagination |
1015-9
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pubmed:dateRevised |
2009-9-29
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pubmed:meshHeading |
pubmed-meshheading:1777160-Cross-Sectional Studies,
pubmed-meshheading:1777160-Great Britain,
pubmed-meshheading:1777160-HIV Antibodies,
pubmed-meshheading:1777160-HIV Core Protein p24,
pubmed-meshheading:1777160-HIV Envelope Protein gp120,
pubmed-meshheading:1777160-HIV Infections,
pubmed-meshheading:1777160-HIV-1,
pubmed-meshheading:1777160-Humans,
pubmed-meshheading:1777160-Kenya,
pubmed-meshheading:1777160-Male,
pubmed-meshheading:1777160-Uganda
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pubmed:year |
1991
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pubmed:articleTitle |
Comparative humoral responses to HIV-1 p24gag and gp120env in subjects from East Africa and the UK.
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pubmed:affiliation |
Department of Medicine, St Mary's Hospital Medical School, London, UK.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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