Linked Life Data

1776916

Source:http://linkedlifedata.com/resource/pubmed/id/1776916

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1992-3-4
pubmed:abstractText
Storage solutions of varying pH have been used for the simple cold preservation of the heart for transplantation. However, few studies have focused on the optimal pH for a storage solution. In the present study, we investigated the effects of storage solutions with 5 different pHs (6.60, 7.00, 7.40, 7.80, and 8.20 at 4 degrees C) on cardiac function, the leakage of cytosolic enzymes, and the myocardial metabolites content. We used the isolated perfused working rat heart model and a 6-hour preservation period in the different storage solutions. We found that cardiac function was best preserved at a pH of 7.00 or 7.80. In the hearts preserved at a pH of 7.00 or 7.80, the leakage of creatine kinase and lactate dehydrogenase was significantly less than at a pH of 7.40 (p less than 0.01). ATP was maintained at a significantly higher concentration in the pH 7.00 solution as compared with the other solutions (p less than 0.01). No significant differences were observed in the creatine phosphate and lactate levels among the five different pH groups. The results showed that the cardiac function and other parameters of cold-preserved hearts were relatively well maintained at both a pH of 7.00 and 7.80, suggesting the possible existence of a biphasic optimum pH for cold preservation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0003-9152
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
60
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
243-9
pubmed:dateRevised
2011-7-27
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
Effects of pH on the cold preservation of the isolated rat heart.
pubmed:affiliation
Second Department of Surgery, Fukui Medical School, Japan.
pubmed:publicationType
Journal Article