pubmed:abstractText |
Different esters of 3-(4'-geranyloxy-3'-methoxyphenyl)-2-trans propenoic acid (1), an anti-inflammatory principle of Acronychia baueri Schott (Rutaceae), were synthesized. Their topical anti-inflammatory activity was evaluated using the Croton oil ear test in mice as a model of acute inflammation. The activity of the paracetamol, guaiacol and hydroquinone esters of (1) was higher than that of the parent compound, being similar to that exerted by indomethacin, used as reference drug.
|
pubmed:affiliation |
Dipartimento di Scienze del Farmaco, Via dei Vestini 31, Università "G. D'Annunzio", Chieti-Pescara 66013 Chieti Scalo (CH), Italy. fepifano@unich.it
|