| pubmed-article:17766682 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17766682 | lifeskim:mentions | umls-concept:C0001554 | lld:lifeskim |
| pubmed-article:17766682 | lifeskim:mentions | umls-concept:C1522424 | lld:lifeskim |
| pubmed-article:17766682 | lifeskim:mentions | umls-concept:C0026336 | lld:lifeskim |
| pubmed-article:17766682 | lifeskim:mentions | umls-concept:C0021027 | lld:lifeskim |
| pubmed-article:17766682 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:17766682 | lifeskim:mentions | umls-concept:C0231174 | lld:lifeskim |
| pubmed-article:17766682 | lifeskim:mentions | umls-concept:C0748342 | lld:lifeskim |
| pubmed-article:17766682 | lifeskim:mentions | umls-concept:C0205266 | lld:lifeskim |
| pubmed-article:17766682 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:17766682 | pubmed:dateCreated | 2007-11-16 | lld:pubmed |
| pubmed-article:17766682 | pubmed:abstractText | Administration of high-dose intact human immunoglobulin (IH-Ig) has been applied to treat a variety of inflammatory and autoimmune diseases, and is expected to have beneficial effects on human fecundity. In the present study, we investigated whether Ig had anti-resorption effects using polyinosinic-polycytidylic acid sodium salt [poly (I:C)]-induced enhancement of fetal resorption in the mating of CBA/J x DBA/2J resorption-prone mouse model. Furthermore, we investigated the mechanism of the effect by examining the mRNA expression of interferon (IFN)-gamma, tumor necrosis factor (TNF)-alpha, IL-10, IL-4 and TGF-beta(1) in spleens and placentas from the resorption-prone model treated with IH-Ig, by reverse transcription (RT)-polymerase chain reaction (PCR). Administration of high-dose IH-Ig significantly reduced the fetal resorption rate from 55% to 10%. This anti-resorption effect, however, was not detected in mice administered with Fab fragments of human Ig. We then performed adoptive transfer experiments to examine whether cellular components could transfer the effect. A remarkable anti-resorption effect was seen in poly (I:C)-injected pregnant recipients transferred with spleen cells from IH-Ig-treated donor mice. The RT-PCR study showed that IH-Ig reduced the expression of IFN-gamma and TNF-alpha mRNA in placentas of poly (I:C)-injected pregnant mice. The present findings demonstrate that intact Ig, particularly its Fc portion, possesses anti-resorption activity. The effect might be attributed to the suppressed production of pro-inflammatory cytokines at the maternofetal interface. | lld:pubmed |
| pubmed-article:17766682 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17766682 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17766682 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17766682 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17766682 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17766682 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17766682 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17766682 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17766682 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17766682 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17766682 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17766682 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17766682 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17766682 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17766682 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:17766682 | pubmed:issn | 1460-2407 | lld:pubmed |
| pubmed-article:17766682 | pubmed:author | pubmed-author:IwabuchiKazuy... | lld:pubmed |
| pubmed-article:17766682 | pubmed:author | pubmed-author:OnoéKazunoriK | lld:pubmed |
| pubmed-article:17766682 | pubmed:author | pubmed-author:MinakamiHisan... | lld:pubmed |
| pubmed-article:17766682 | pubmed:author | pubmed-author:YamadaHidetoH | lld:pubmed |
| pubmed-article:17766682 | pubmed:author | pubmed-author:SakuragiNoria... | lld:pubmed |
| pubmed-article:17766682 | pubmed:author | pubmed-author:NaitoMakotoM | lld:pubmed |
| pubmed-article:17766682 | pubmed:author | pubmed-author:ShimadaShigek... | lld:pubmed |
| pubmed-article:17766682 | pubmed:author | pubmed-author:TakedaMasamit... | lld:pubmed |
| pubmed-article:17766682 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:17766682 | pubmed:volume | 13 | lld:pubmed |
| pubmed-article:17766682 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17766682 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17766682 | pubmed:pagination | 807-14 | lld:pubmed |
| pubmed-article:17766682 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:17766682 | pubmed:meshHeading | pubmed-meshheading:17766682... | lld:pubmed |
| pubmed-article:17766682 | pubmed:meshHeading | pubmed-meshheading:17766682... | lld:pubmed |
| pubmed-article:17766682 | pubmed:meshHeading | pubmed-meshheading:17766682... | lld:pubmed |
| pubmed-article:17766682 | pubmed:meshHeading | pubmed-meshheading:17766682... | lld:pubmed |
| pubmed-article:17766682 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17766682 | pubmed:articleTitle | Administration of high-dose intact immunoglobulin has an anti-resorption effect in a mouse model of reproductive failure. | lld:pubmed |
| pubmed-article:17766682 | pubmed:affiliation | Division of Immunobiology, Research Section of Pathophysiology, Institute for Genetic Medicine, Hokkaido University, Kita-15, Nishi-7, Kita-ku, Sapporo, Hokkaido, Japan. | lld:pubmed |
| pubmed-article:17766682 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17766682 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
