Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
37
pubmed:dateCreated
2007-9-12
pubmed:abstractText
Cellular organization into epithelial architecture maintains structural integrity and homeostasis by suppressing cell proliferation and apoptosis. However, it is unclear whether the epithelial organization is sufficient to block induction of cell-autonomous cell cycle progression and apoptotic sensitivity by activated oncogenes. We show that chronic activation of oncogenic c-Myc, starting in the developing 3D organotypic mammary acinar structures, results in hyperproliferation and transformed acinar morphology. Surprisingly, acute c-Myc activation in mature quiescent acini with established epithelial architecture fails to reinitiate the cell cycle or transform these structures. c-Myc does reinitiate the cell cycle in quiescent, but structurally unorganized, acini, which demonstrates that proper epithelial architecture is needed for the proliferation blockade. The capability of c-Myc to reinitiate the cell cycle in acinar structures is also restored by the loss of LKB1, a human homologue of the cell polarity protein PAR4. The epithelial architecture also restrains the apoptotic activity of c-Myc, but coactivation of c-Myc and a complementary TNF-related apoptosis-inducing ligand death receptor pathway can induce a strong Bim and Bid-mediated apoptotic response in the established acini. The results together expose surprising proliferation and apoptosis resistance of organized epithelial structures and identify a role for the polarity regulator LKB1 in the development of c-Myc-resistant cell organization.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/17766436-11064676, http://linkedlifedata.com/resource/pubmed/commentcorrection/17766436-11509733, http://linkedlifedata.com/resource/pubmed/commentcorrection/17766436-12242153, http://linkedlifedata.com/resource/pubmed/commentcorrection/17766436-12372298, http://linkedlifedata.com/resource/pubmed/commentcorrection/17766436-12766184, http://linkedlifedata.com/resource/pubmed/commentcorrection/17766436-12798140, http://linkedlifedata.com/resource/pubmed/commentcorrection/17766436-14551319, http://linkedlifedata.com/resource/pubmed/commentcorrection/17766436-15016379, http://linkedlifedata.com/resource/pubmed/commentcorrection/17766436-15079075, http://linkedlifedata.com/resource/pubmed/commentcorrection/17766436-15183188, http://linkedlifedata.com/resource/pubmed/commentcorrection/17766436-15261145, http://linkedlifedata.com/resource/pubmed/commentcorrection/17766436-15314019, http://linkedlifedata.com/resource/pubmed/commentcorrection/17766436-15800014, http://linkedlifedata.com/resource/pubmed/commentcorrection/17766436-16148884, http://linkedlifedata.com/resource/pubmed/commentcorrection/17766436-17088526, http://linkedlifedata.com/resource/pubmed/commentcorrection/17766436-17114342, http://linkedlifedata.com/resource/pubmed/commentcorrection/17766436-17268552, http://linkedlifedata.com/resource/pubmed/commentcorrection/17766436-3467345, http://linkedlifedata.com/resource/pubmed/commentcorrection/17766436-8622967
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0027-8424
pubmed:author
pubmed:issnType
Print
pubmed:day
11
pubmed:volume
104
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
14694-9
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Suppression of oncogenic properties of c-Myc by LKB1-controlled epithelial organization.
pubmed:affiliation
Cancer Cell Circuitry Laboratory, Institute of Biomedicine/Biochemistry and Genome-Scale Biology Program, Biomedicum Helsinki, University of Helsinki, Room B231a, PO Box 63, Haartmaninkatu 8, 00014, Helsinki, Finland.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't