Source:http://linkedlifedata.com/resource/pubmed/id/17763321
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
7
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pubmed:dateCreated |
2007-8-31
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pubmed:abstractText |
We conducted a retrospective study of 65 patients with chronic hepatitis C, to determine whether the secondary structure of the amino-terminal 120 residues of the hepatitis C virus (HCV) NS3 protein is associated with an increased risk of development of hepatocellular carcinoma (HCC). The cumulative incidence of HCC was highest among patients infected with group B HCV-1b, wherein the risk of HCC significantly increased compared with that among patients infected with group A (hazard ratio, 4.95 [95% CI, 1.43-17.11]) after adjustment for age and histological stage. This HCV-1b grouping may be a useful marker for detecting the risk of development of HCC.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0022-1899
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
196
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1006-9
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pubmed:meshHeading |
pubmed-meshheading:17763321-Adult,
pubmed-meshheading:17763321-Aged,
pubmed-meshheading:17763321-Carcinoma, Hepatocellular,
pubmed-meshheading:17763321-Female,
pubmed-meshheading:17763321-Hepacivirus,
pubmed-meshheading:17763321-Hepatitis C, Chronic,
pubmed-meshheading:17763321-Humans,
pubmed-meshheading:17763321-Incidence,
pubmed-meshheading:17763321-Liver Neoplasms,
pubmed-meshheading:17763321-Male,
pubmed-meshheading:17763321-Middle Aged,
pubmed-meshheading:17763321-Proportional Hazards Models,
pubmed-meshheading:17763321-Protein Structure, Secondary,
pubmed-meshheading:17763321-Risk Factors,
pubmed-meshheading:17763321-Viral Nonstructural Proteins
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pubmed:year |
2007
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pubmed:articleTitle |
Risk of hepatocellular carcinoma and secondary structure of hepatitis C virus (HCV) NS3 protein amino-terminus, in patients infected with HCV subtype 1b.
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pubmed:affiliation |
Department of Gastroenterology, Yamagata University Faculty of Medicine, Yamagata 990-9585, Japan. ynishise-gi@umin.ac.jp
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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