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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2008-2-7
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pubmed:abstractText |
The purpose of this study was to investigate whether taurine ameliorate the diabetic retinopathy, and to further explore the underlying mechanisms. The Sprague-Dawley rats were injected with streptozotocin to establish experimental diabetic model, then fed without or with 1.2% taurine for additional 4-12 weeks. After that, the protective effects of dietary taurine supplementation on diabetic retinopathy were estimated. Our results showed that chronic taurine supplement effectively improved diabetic retinopathy as changes of histopathology and ultrastructure. The supplementation could not lower plasma glucose concentration (P > 0.05), but caused an elevation in taurine content and a decline in levels of glutamate and gamma-aminobutyric acid (GABA) in diabetic retina (P < 0.05). Moreover, chronic taurine supplementation increased glutamate transporter (GLAST) expression (P < 0.05), decreased intermediate filament glial fibrillary acidic protein (GFAP) and N-methyl-D: -aspartate receptor subunit 1 (NR1) expression in diabetic retina (P < 0.05). These results demonstrated that chronic taurine supplementation ameliorates diabetic retinopathy via anti-excitotoxicity of glutamate in rats.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Amino Acid Transport System X-AG,
http://linkedlifedata.com/resource/pubmed/chemical/Blood Glucose,
http://linkedlifedata.com/resource/pubmed/chemical/Excitatory Amino Acid Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Excitatory Amino Acid Transporter 1,
http://linkedlifedata.com/resource/pubmed/chemical/Glial Fibrillary Acidic Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Glutamic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/NR1 NMDA receptor,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, N-Methyl-D-Aspartate,
http://linkedlifedata.com/resource/pubmed/chemical/Slc1a3 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Taurine,
http://linkedlifedata.com/resource/pubmed/chemical/gamma-Aminobutyric Acid
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0364-3190
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pubmed:author |
pubmed-author:EronJ JJJ,
pubmed-author:MiMantianM,
pubmed-author:TangYongY,
pubmed-author:WangJianJ,
pubmed-author:XuHongxiaH,
pubmed-author:XuZhaoxiaZ,
pubmed-author:YehTT,
pubmed-author:YuV PVP,
pubmed-author:YuXiaopingX,
pubmed-author:ZengKaihongK,
pubmed-author:ZhangQianyongQ,
pubmed-author:ZhuJundongJ
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pubmed:issnType |
Print
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pubmed:volume |
33
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
500-7
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pubmed:meshHeading |
pubmed-meshheading:17762918-Amino Acid Transport System X-AG,
pubmed-meshheading:17762918-Animals,
pubmed-meshheading:17762918-Blood Glucose,
pubmed-meshheading:17762918-Blotting, Western,
pubmed-meshheading:17762918-Body Weight,
pubmed-meshheading:17762918-Diabetes Mellitus, Experimental,
pubmed-meshheading:17762918-Diabetic Retinopathy,
pubmed-meshheading:17762918-Dietary Supplements,
pubmed-meshheading:17762918-Excitatory Amino Acid Antagonists,
pubmed-meshheading:17762918-Excitatory Amino Acid Transporter 1,
pubmed-meshheading:17762918-Glial Fibrillary Acidic Protein,
pubmed-meshheading:17762918-Glutamic Acid,
pubmed-meshheading:17762918-Rats,
pubmed-meshheading:17762918-Rats, Sprague-Dawley,
pubmed-meshheading:17762918-Receptors, N-Methyl-D-Aspartate,
pubmed-meshheading:17762918-Retina,
pubmed-meshheading:17762918-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:17762918-Taurine,
pubmed-meshheading:17762918-gamma-Aminobutyric Acid
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pubmed:year |
2008
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pubmed:articleTitle |
Dietary taurine supplementation ameliorates diabetic retinopathy via anti-excitotoxicity of glutamate in streptozotocin-induced Sprague-Dawley rats.
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pubmed:affiliation |
Department of Public Health, School of Preclinical Medicine, Chengdu Medical College, 601 Rongdu Road, Jinniu District, Chengdu 610081, China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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