| pubmed-article:17762167 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17762167 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:17762167 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:17762167 | lifeskim:mentions | umls-concept:C0227525 | lld:lifeskim |
| pubmed-article:17762167 | lifeskim:mentions | umls-concept:C0007447 | lld:lifeskim |
| pubmed-article:17762167 | lifeskim:mentions | umls-concept:C0033634 | lld:lifeskim |
| pubmed-article:17762167 | lifeskim:mentions | umls-concept:C0086597 | lld:lifeskim |
| pubmed-article:17762167 | lifeskim:mentions | umls-concept:C0439799 | lld:lifeskim |
| pubmed-article:17762167 | lifeskim:mentions | umls-concept:C0872351 | lld:lifeskim |
| pubmed-article:17762167 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:17762167 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:17762167 | pubmed:dateCreated | 2007-8-31 | lld:pubmed |
| pubmed-article:17762167 | pubmed:abstractText | We were interested whether PKC alpha, delta, epsilon or zeta is the isoform actually employed in the activation of hypertonicity-induced cation channels (HICCs) in primary cultures of rat hepatocytes. Quantitative SDS-page and Western-blot experiments revealed that PKC alpha, delta and epsilon were stimulated by Indolactam V (as a DAG substitute for activation of c and nPKCs) but that only PKC delta and epsilon did respond to hypertonic stress. Furthermore, chelation of intracellular Ca(++) by BAPTA-AM did not alter HICC activation in cable-analysis experiments whereas Indolactam V as well as V8 (an Indolactam derivative specific for PKC delta and epsilon) activated HICC currents under isotonic conditions. Finally, by use of Rottlerin (as an inhibitor exhibiting a slight preference for PKC delta over epsilon) PKC epsilon could be identified as the most likely isoform responsible for the activation of the HICC. | lld:pubmed |
| pubmed-article:17762167 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17762167 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17762167 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17762167 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17762167 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17762167 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17762167 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17762167 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17762167 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17762167 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17762167 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17762167 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17762167 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17762167 | pubmed:issn | 1015-8987 | lld:pubmed |
| pubmed-article:17762167 | pubmed:author | pubmed-author:WaldmannHerbe... | lld:pubmed |
| pubmed-article:17762167 | pubmed:author | pubmed-author:WehnerFrankF | lld:pubmed |
| pubmed-article:17762167 | pubmed:author | pubmed-author:RosenbaumClau... | lld:pubmed |
| pubmed-article:17762167 | pubmed:author | pubmed-author:LinChiann-Tso... | lld:pubmed |
| pubmed-article:17762167 | pubmed:author | pubmed-author:BierhalsKatri... | lld:pubmed |
| pubmed-article:17762167 | pubmed:author | pubmed-author:SondersorgAnn... | lld:pubmed |
| pubmed-article:17762167 | pubmed:copyrightInfo | Copyright (c) 2007 S. Karger AG, Basel. | lld:pubmed |
| pubmed-article:17762167 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17762167 | pubmed:volume | 20 | lld:pubmed |
| pubmed-article:17762167 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17762167 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17762167 | pubmed:pagination | 397-404 | lld:pubmed |
| pubmed-article:17762167 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:17762167 | pubmed:meshHeading | pubmed-meshheading:17762167... | lld:pubmed |
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| pubmed-article:17762167 | pubmed:meshHeading | pubmed-meshheading:17762167... | lld:pubmed |
| pubmed-article:17762167 | pubmed:meshHeading | pubmed-meshheading:17762167... | lld:pubmed |
| pubmed-article:17762167 | pubmed:meshHeading | pubmed-meshheading:17762167... | lld:pubmed |
| pubmed-article:17762167 | pubmed:meshHeading | pubmed-meshheading:17762167... | lld:pubmed |
| pubmed-article:17762167 | pubmed:meshHeading | pubmed-meshheading:17762167... | lld:pubmed |
| pubmed-article:17762167 | pubmed:meshHeading | pubmed-meshheading:17762167... | lld:pubmed |
| pubmed-article:17762167 | pubmed:meshHeading | pubmed-meshheading:17762167... | lld:pubmed |
| pubmed-article:17762167 | pubmed:meshHeading | pubmed-meshheading:17762167... | lld:pubmed |
| pubmed-article:17762167 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17762167 | pubmed:articleTitle | The epsilon-isoform of PKC mediates the hypertonic activation of cation channels in confluent monolayers of rat hepatocytes. | lld:pubmed |
| pubmed-article:17762167 | pubmed:affiliation | Department of Systemic Cell Biology, Max-Planck-Institute for Molecular Physiology, Dortmund, Germany. | lld:pubmed |
| pubmed-article:17762167 | pubmed:publicationType | Journal Article | lld:pubmed |
| entrez-gene:29340 | entrezgene:pubmed | pubmed-article:17762167 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:17762167 | lld:entrezgene |
