HIV-related lipodystrophy is a syndrome of adipose tissue redistribution, dyslipidaemia and insulin resistance. Combination antiretroviral therapy (CART) is a key risk factor. We hypothesized that fat redistribution in HIV-infected children is related to altered endocrine function of adipose tissue, namely leptin secretion.
Infectious Diseases and Microbiology Unit, University College London Institute of Child Health, and Clinical Infectious Diseases Unit, Great Ormond Street Children's Hospital NHS Trust, London, UK.