Linked Life Data

17760433

Source:http://linkedlifedata.com/resource/pubmed/id/17760433

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
20
pubmed:dateCreated
2007-9-27
pubmed:abstractText
To address the dependence of GRIND-based 3D-QSAR on data set flexibility, we investigate a series of oxidosqualene cyclase (OSC) inhibitors. The results indicate that statistical models are determined independently of the data set but that despite identification of the same outliers and the acceptable test set prediction, not all models show good predictive correlation coefficient (q2). Moreover, the best model was obtained using a data set of the lowest energy conformers generated by a conformational analysis.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0022-2623
pubmed:author
pubmed:issnType
Print
pubmed:day
4
pubmed:volume
50
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
5039-42
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Influence of conformation on GRIND-based three-dimensional quantitative structure-activity relationship (3D-QSAR).
pubmed:affiliation
CASMedChem Laboratory, Dipartimento di Scienza e Tecnologia del Farmaco, Università di Torino, Via P. Giuria, 9, 10125 Torino, Italy.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't