Linked Life Data

1773827

Source:http://linkedlifedata.com/resource/pubmed/id/1773827

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1992-3-5
pubmed:abstractText
Tetrahydroaminoacridine discriminated slightly in its potency to displace [3H]N-methylscopolamine ([3H]NMS) binding from different muscarinic receptor subtypes (M2 greater than M1 greater than M3) and to allosterically decelerate ligand binding (M2 greater than or equal to M1 greater than M3). The steep displacement curves suggest that marked changes in receptor occupancy may occur within a relatively narrow dose range. Thus, individual inter-patient variability and inconsistent results in clinical studies may be related to blockade of muscarinic receptors, which would oppose the beneficial effects resulting from acetylcholinesterase inhibition.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0014-2999
pubmed:author
pubmed:issnType
Print
pubmed:day
22
pubmed:volume
203
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
421-3
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
Muscarinic subtype selectivity of tetrahydroaminoacridine: possible relationship to its capricious efficacy.
pubmed:affiliation
Department of Pharmacology and Toxicology, University of Maryland School of Pharmacy, Baltimore 21201.
pubmed:publicationType
Journal Article, In Vitro, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't