Linked Life Data

1773482

Source:http://linkedlifedata.com/resource/pubmed/id/1773482

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1992-3-4
pubmed:abstractText
Intravenous glucose tolerance tests (IVGTTs) using 1.2 g/kg of D-glucose in fasted, male rats were repeated twice, with an interval of 75 min, during early (2.5 hr) and late (26.5 hr) nonlethal endotoxicosis induced by Salmonella enteritidis endotoxin (ETX) at 10 micrograms/kg i.v. In comparison with saline controls, glucose tolerance was dramatically increased in early endotoxicosis; however, it was restored to near normal in late endotoxicosis. Augmentation of tolerance by repeated IVGTTs i.e. the Staub-Traugott effect, occurred in the saline control groups; however, it was absent in both early and late endotoxicosis. The elevations of plasma insulin (IRI) in response to the glucose loads were exaggerated vs. controls in both early and late endotoxicosis; however, the hyperinsulinemias were not significantly diminished by repeated IVGTTs in any group. These results indicate loss of the Staub-Traugott effect in endotoxicosis that is 1) independent of augmented insulin secretory responses to a repeated glucose challenge and 2) dependent on some adaptive cellular mechanisms to repeated glucose loads which were impaired in nonlethal endotoxicosis.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0092-6213
pubmed:author
pubmed:issnType
Print
pubmed:volume
34
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
398-404
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
Absence of the Staub-Traugott effect in endotoxicosis.
pubmed:affiliation
Department of Physiology, Loyola University Chicago Medical Center, Maywood, IL 60153.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.