Source:http://linkedlifedata.com/resource/pubmed/id/17726701
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
10
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pubmed:dateCreated |
2007-9-4
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pubmed:abstractText |
After closure of the Epidemiologic Registry of Cystic Fibrosis (ERCF), a comprehensive safety analysis of dornase alfa was performed. A planned subanalysis focused on children under 5 years old. Reported serious adverse events (SAEs) were assigned a preferred term and ascribed to a specific organ system. Possible serious adverse reactions to dornase alfa (SADRs) were identified by reporting clinics. Twenty-eight of 15,865 SAEs (0.18%), occurring in 26 of 6,829 patients ever treated with dornase alfa (0.38%), and no deaths were reported as possible SADRs: most were typical complications of cystic fibrosis (CF). There was no evidence of any unrecognized risk of treatment. During 24,586 patient-years of follow-up (FU) of ever-treated patients, SAEs (mostly typical respiratory complications of CF) were more frequent on-treatment (0.4999/patient-year; 95% CI 0.4921-0.5076) than off-treatment (0.3889; 0.3787-0.3992). This was likely caused by within-patient prescription bias. During 655 patient-years of FU in 328 ever-treated patients under 5 years old, SAEs (mostly pulmonary exacerbations of CF) were slightly less frequent during treatment: 0.2911 (0.2367-0.3455) versus 0.3563 (0.3086-0.4040; ns). Results confirm the safety of dornase alfa in CF patients of all ages. Children under 5 years old tolerate dornase alfa at least as well as older patients.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
8755-6863
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pubmed:author | |
pubmed:copyrightInfo |
(c) 2007 Wiley-Liss, Inc.
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pubmed:issnType |
Print
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pubmed:volume |
42
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
928-37
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pubmed:meshHeading |
pubmed-meshheading:17726701-Child, Preschool,
pubmed-meshheading:17726701-Cystic Fibrosis,
pubmed-meshheading:17726701-Deoxyribonuclease I,
pubmed-meshheading:17726701-Expectorants,
pubmed-meshheading:17726701-Humans,
pubmed-meshheading:17726701-Infant,
pubmed-meshheading:17726701-Infant, Newborn,
pubmed-meshheading:17726701-Recombinant Proteins,
pubmed-meshheading:17726701-Registries
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pubmed:year |
2007
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pubmed:articleTitle |
Dornase alfa is well tolerated: data from the epidemiologic registry of cystic fibrosis.
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pubmed:affiliation |
F. Hoffmann-La Roche Ltd, Basel, Switzerland.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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