Linked Life Data

1772648

Source:http://linkedlifedata.com/resource/pubmed/id/1772648

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
1992-2-28
pubmed:abstractText
Tumors were induced in athymic, T-cell-deficient nude mice and in syngeneic normal haired mice by treatment with low doses of 3-methylcholantrene (MCA). The tumors were studied for tumor cell expression of MHC class I molecules and for immunogenicity by transplantation to syngeneic haired recipients. Ten tumors were obtained by the MCA treatment, six from nude and four from haired mice. They were all fibrosarcomas as judged from their microscopic appearance. Five of the "nude" tumors expressed measurable amounts of MHC class I molecules and two of them expressed high amounts. Both were immunogenic in the sense that they evoked a cytotoxic T-cell response in transplanted haired recipients. Only one of the four "haired" tumors expressed measurable amounts of MHC class I, and none of them were immunogenic. These findings support the concept that some tumors are immunoselected at an early point of time in their existence in a host with a normal immune system and that this results in an elimination of tumor cell variants which are highly immunogenic for the T-cell system, leaving the low or non-immunogenic variants. These take over and grow and kill their host. The results suggest that tumor cell variants expressing high amounts of MHC class I are important targets in the immunoselection in hosts with a normal immune system.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0903-4641
pubmed:author
pubmed:issnType
Print
pubmed:volume
99
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1111-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
Tumors developing in nude mice express unusually large amounts of MHC class I antigens.
pubmed:affiliation
Institute for Experimental Immunology, University of Copenhagen, Denmark.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't