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rdf:type |
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lifeskim:mentions |
umls-concept:C0002085,
umls-concept:C0012155,
umls-concept:C0019904,
umls-concept:C0035527,
umls-concept:C0035647,
umls-concept:C0043210,
umls-concept:C0178638,
umls-concept:C0205251,
umls-concept:C0232970,
umls-concept:C0681842,
umls-concept:C0919427,
umls-concept:C1838660
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pubmed:issue |
1
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pubmed:dateCreated |
2007-12-31
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pubmed:abstractText |
The MTHFR C677T polymorphism is associated with mildly elevated homocysteine levels when folate and/or riboflavin status is low. Furthermore, a mildly elevated homocysteine level is a risk factor for osteoporotic fractures. We studied whether dietary intake of riboflavin and folate modifies the effects of the MTHFR C677T variant on fracture risk in 5,035 men and women from the Rotterdam Study. We found that the MTHFR C677T variant interacts with dietary riboflavin intake to influence fracture risk in women.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0884-0431
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
23
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
86-94
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pubmed:meshHeading |
pubmed-meshheading:17725378-Aged,
pubmed-meshheading:17725378-Alleles,
pubmed-meshheading:17725378-Bone Density,
pubmed-meshheading:17725378-Cohort Studies,
pubmed-meshheading:17725378-Female,
pubmed-meshheading:17725378-Folic Acid,
pubmed-meshheading:17725378-Folic Acid Deficiency,
pubmed-meshheading:17725378-Fractures, Bone,
pubmed-meshheading:17725378-Genotype,
pubmed-meshheading:17725378-Homocysteine,
pubmed-meshheading:17725378-Humans,
pubmed-meshheading:17725378-Incidence,
pubmed-meshheading:17725378-Male,
pubmed-meshheading:17725378-Methylenetetrahydrofolate Reductase (NADPH2),
pubmed-meshheading:17725378-Middle Aged,
pubmed-meshheading:17725378-Osteoporosis, Postmenopausal,
pubmed-meshheading:17725378-Postmenopause,
pubmed-meshheading:17725378-Riboflavin,
pubmed-meshheading:17725378-Riboflavin Deficiency,
pubmed-meshheading:17725378-Risk Factors
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pubmed:year |
2008
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pubmed:articleTitle |
Low dietary riboflavin but not folate predicts increased fracture risk in postmenopausal women homozygous for the MTHFR 677 T allele.
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pubmed:affiliation |
Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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