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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2007-8-28
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pubmed:abstractText |
Mutations in the Parkin and PINK1 genes can cause parkinsonism. Since asymptomatic carriers of a single mutant allele of the Parkin or PINK1 gene display a presynaptic dopaminergic dysfunction in the striatum, they provide a unique in vivo model to study structural and functional reorganization in response to latent nigrostriatal dysfunction. We hypothesized that subclinical nigrostriatal neurodegeneration caused by these mutations would induce morphologic changes in the dysfunctional striatal gray matter.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1526-632X
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pubmed:author |
pubmed-author:BüchelCC,
pubmed-author:BinkofskiFF,
pubmed-author:GaserCC,
pubmed-author:HagenahJJ,
pubmed-author:HedrickNN,
pubmed-author:HilkerRR,
pubmed-author:KleinCC,
pubmed-author:PramstallerP PPP,
pubmed-author:ReetzKK,
pubmed-author:SiebnerH RHR,
pubmed-author:ThielAA,
pubmed-author:van EimerenTT
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pubmed:issnType |
Electronic
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pubmed:day |
28
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pubmed:volume |
69
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
842-50
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:17724286-Adult,
pubmed-meshheading:17724286-Basal Ganglia Diseases,
pubmed-meshheading:17724286-Corpus Striatum,
pubmed-meshheading:17724286-DNA Mutational Analysis,
pubmed-meshheading:17724286-Dihydroxyphenylalanine,
pubmed-meshheading:17724286-Dopamine,
pubmed-meshheading:17724286-Female,
pubmed-meshheading:17724286-Genetic Predisposition to Disease,
pubmed-meshheading:17724286-Genetic Testing,
pubmed-meshheading:17724286-Genotype,
pubmed-meshheading:17724286-Globus Pallidus,
pubmed-meshheading:17724286-Heterozygote,
pubmed-meshheading:17724286-Humans,
pubmed-meshheading:17724286-Magnetic Resonance Imaging,
pubmed-meshheading:17724286-Male,
pubmed-meshheading:17724286-Middle Aged,
pubmed-meshheading:17724286-Mutation,
pubmed-meshheading:17724286-Positron-Emission Tomography,
pubmed-meshheading:17724286-Protein Kinases,
pubmed-meshheading:17724286-Putamen,
pubmed-meshheading:17724286-Ubiquitin-Protein Ligases
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pubmed:year |
2007
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pubmed:articleTitle |
Morphometric fingerprint of asymptomatic Parkin and PINK1 mutation carriers in the basal ganglia.
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pubmed:affiliation |
Department of Neurology, University Hospital Schleswig-Holstein, Campus Luebeck, Luebeck, Germany. ferdinand.binkofski@neuro.uni-luebeck.de
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Intramural
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