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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2007-8-28
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pubmed:abstractText |
The proteolytic activity of matrix metalloproteinases (MMPs) is involved in pathologic angiogenesis in the eye. However, it is unknown whether MMPs may stimulate the production of the major angiogenic factor, vascular endothelial growth factor (VEGF). The authors investigated whether MMP-2 and MMP-9 alter the expression of VEGF by retinal pigment epithelial (RPE) cells. They also sought to determine the effects of MMPs on cellular proliferation and migration and the effect of triamcinolone acetonide on MMP-9-evoked cellular responses.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0146-0404
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
48
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4360-7
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:17724228-Cell Hypoxia,
pubmed-meshheading:17724228-Cell Movement,
pubmed-meshheading:17724228-Cell Proliferation,
pubmed-meshheading:17724228-Cells, Cultured,
pubmed-meshheading:17724228-Feedback, Physiological,
pubmed-meshheading:17724228-Gene Expression Regulation,
pubmed-meshheading:17724228-Glucocorticoids,
pubmed-meshheading:17724228-Humans,
pubmed-meshheading:17724228-Matrix Metalloproteinase 2,
pubmed-meshheading:17724228-Matrix Metalloproteinase 9,
pubmed-meshheading:17724228-Pigment Epithelium of Eye,
pubmed-meshheading:17724228-RNA, Messenger,
pubmed-meshheading:17724228-Triamcinolone Acetonide,
pubmed-meshheading:17724228-Up-Regulation,
pubmed-meshheading:17724228-Vascular Endothelial Growth Factor A
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pubmed:year |
2007
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pubmed:articleTitle |
Positive feedback regulation between MMP-9 and VEGF in human RPE cells.
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pubmed:affiliation |
Department of Ophthalmology and Eye Clinic, University of Leipzig Faculty of Medicine, Leipzig, Germany. hollbm@medizin.uni-leipzig.de
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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