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rdf:type |
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lifeskim:mentions |
umls-concept:C0010031,
umls-concept:C0014038,
umls-concept:C0026809,
umls-concept:C0037083,
umls-concept:C0037274,
umls-concept:C0851827,
umls-concept:C1280500,
umls-concept:C1302234,
umls-concept:C1332822,
umls-concept:C1527148,
umls-concept:C1701901,
umls-concept:C1710082
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pubmed:issue |
9
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pubmed:dateCreated |
2007-8-28
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pubmed:abstractText |
The host inflammatory response to ocular infection with herpes simplex virus (HSV) can be either protective, with disease-free survival, or it can promote diseases such as HSV corneal disease (or herpes stromal keratitis [HSK] in humans) and encephalitis (HSE), depending on mouse strain. The role of CXCR3 chemokine signaling in HSV-induced central nervous system (CNS) inflammation and corneal disease was evaluated, and responses in genetically susceptible and resistant strains of mice were contrasted.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/CXCR3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokine CXCL10,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokine CXCL9,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokines, CXC,
http://linkedlifedata.com/resource/pubmed/chemical/Cxcl9 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Cxcr3 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, CXCR3,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Chemokine
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0146-0404
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
48
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4162-70
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:17724202-Animals,
pubmed-meshheading:17724202-Brain Stem,
pubmed-meshheading:17724202-Chemokine CXCL10,
pubmed-meshheading:17724202-Chemokine CXCL9,
pubmed-meshheading:17724202-Chemokines, CXC,
pubmed-meshheading:17724202-Cornea,
pubmed-meshheading:17724202-Disease Susceptibility,
pubmed-meshheading:17724202-Encephalitis, Herpes Simplex,
pubmed-meshheading:17724202-Flow Cytometry,
pubmed-meshheading:17724202-Herpesvirus 1, Human,
pubmed-meshheading:17724202-Immunity, Innate,
pubmed-meshheading:17724202-Keratitis, Herpetic,
pubmed-meshheading:17724202-Mice,
pubmed-meshheading:17724202-Mice, Inbred BALB C,
pubmed-meshheading:17724202-Mice, Inbred C57BL,
pubmed-meshheading:17724202-Receptors, CXCR3,
pubmed-meshheading:17724202-Receptors, Chemokine,
pubmed-meshheading:17724202-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:17724202-Signal Transduction,
pubmed-meshheading:17724202-Skin Diseases, Viral,
pubmed-meshheading:17724202-Trigeminal Ganglion,
pubmed-meshheading:17724202-Up-Regulation
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pubmed:year |
2007
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pubmed:articleTitle |
Effects of CXCR3 signaling on development of fatal encephalitis and corneal and periocular skin disease in HSV-infected mice are mouse-strain dependent.
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pubmed:affiliation |
Division of Virology, Beckman Research Institute, City of Hope, Duarte, CA 91010, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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