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rdf:type |
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lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0073209,
umls-concept:C0086418,
umls-concept:C0086860,
umls-concept:C0185117,
umls-concept:C0206427,
umls-concept:C0206428,
umls-concept:C0599894,
umls-concept:C1552915,
umls-concept:C1705186,
umls-concept:C1947942,
umls-concept:C2347970,
umls-concept:C2347971,
umls-concept:C2911684
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|
pubmed:issue |
9
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|
pubmed:dateCreated |
2007-8-28
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|
pubmed:abstractText |
Gene therapy for retinal degeneration requires well-defined promoters that drive expression in rod and cone photoreceptors. This study was undertaken to develop short, active derivatives of the human rhodopsin kinase (RK) gene promoter for targeting transgene expression in rods and cones. RK, also known as G protein-coupled receptor kinase 1 (GRK1), is a component of the light adaptation pathway expressed in rods and cones.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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|
pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0146-0404
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
48
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3954-61
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:17724172-Animals,
pubmed-meshheading:17724172-Dependovirus,
pubmed-meshheading:17724172-G-Protein-Coupled Receptor Kinase 1,
pubmed-meshheading:17724172-Gene Expression,
pubmed-meshheading:17724172-Gene Targeting,
pubmed-meshheading:17724172-Genetic Vectors,
pubmed-meshheading:17724172-Green Fluorescent Proteins,
pubmed-meshheading:17724172-Kidney,
pubmed-meshheading:17724172-Luminescent Agents,
pubmed-meshheading:17724172-Mice,
pubmed-meshheading:17724172-Photoreceptor Cells, Vertebrate,
pubmed-meshheading:17724172-Plasmids,
pubmed-meshheading:17724172-Promoter Regions, Genetic,
pubmed-meshheading:17724172-Rats,
pubmed-meshheading:17724172-Retinal Neoplasms,
pubmed-meshheading:17724172-Retinoblastoma,
pubmed-meshheading:17724172-Rod Opsins,
pubmed-meshheading:17724172-Transfection,
pubmed-meshheading:17724172-Transgenes,
pubmed-meshheading:17724172-Tumor Cells, Cultured
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pubmed:year |
2007
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pubmed:articleTitle |
AAV-mediated expression targeting of rod and cone photoreceptors with a human rhodopsin kinase promoter.
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pubmed:affiliation |
Department of Ophthalmology, Ross Eye Institute, State University of New York, Buffalo, New York 14215, USA. skhani@buffalo.edu
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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