|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
1-2
|
|
pubmed:dateCreated |
2007-9-17
|
|
pubmed:abstractText |
The study investigated the time course of the effects of acoustic and electric stimulation on the electrically evoked compound action potential (ECAP). Adult guinea pigs were used in acute experimental sessions. Bursts of acoustic noise and high-rate (5000 pulses/s) electric pulse trains were used as maskers. Biphasic electric pulses were used as probes. ECAPs were recorded from the auditory nerve trunk. Simultaneous masking of the ECAP with acoustic noise featured an onset effect and a decrease in the amount of masking to a steady state. It was characterized by a two-component exponential function. The amount of masking increased with masker level and decreased with probe level. Post-stimulatory ECAP recovery often featured a non-monotonic time course, described by a three-component exponent. Electric maskers produced similar post-stimulatory effects in hearing and acutely deafened subjects. Acoustic stimulation affects the ECAP in a level- and time-dependent manner. Simultaneous masking follows a time course comparable to that of adaptation to an acoustic stimulus. Refractoriness, spontaneous activity, and adaptation are suggested to play a role in ECAP recovery. Post-stimulatory changes in synchrony, possibly due to recovery of spontaneous activity and an additional hair-cell independent mechanism, are hypothesized to contribute to the observed non-monotonicity of recovery.
|
|
pubmed:grant |
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17723284-10545807,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17723284-10777022,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17723284-11033251,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17723284-11335071,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17723284-11508961,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17723284-11669395,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17723284-11801948,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17723284-12704085,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17723284-14587606,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17723284-14599695,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17723284-14746514,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17723284-15101651,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17723284-15157960,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17723284-15205547,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17723284-15224850,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17723284-15604914,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17723284-15811706,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17723284-16079632,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17723284-16092537,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17723284-16708257,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17723284-16864490,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17723284-17063011,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17723284-17063013,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17723284-2010805,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17723284-479921,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17723284-6480511,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17723284-6480516,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17723284-6501113,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17723284-6707972,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17723284-707064,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17723284-7142045,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17723284-7400049,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17723284-7737931,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17723284-8572135,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17723284-903799,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17723284-9213127,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17723284-9596182,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17723284-9641327,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17723284-9888192,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17723284-9925022
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Oct
|
|
pubmed:issn |
0378-5955
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
232
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
87-103
|
|
pubmed:dateRevised |
2009-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:17723284-Acoustic Stimulation,
pubmed-meshheading:17723284-Adaptation, Physiological,
pubmed-meshheading:17723284-Animals,
pubmed-meshheading:17723284-Auditory Perception,
pubmed-meshheading:17723284-Cochlear Nerve,
pubmed-meshheading:17723284-Deafness,
pubmed-meshheading:17723284-Disease Models, Animal,
pubmed-meshheading:17723284-Electric Stimulation,
pubmed-meshheading:17723284-Evoked Potentials, Auditory,
pubmed-meshheading:17723284-Furosemide,
pubmed-meshheading:17723284-Guinea Pigs,
pubmed-meshheading:17723284-Models, Neurological,
pubmed-meshheading:17723284-Neomycin,
pubmed-meshheading:17723284-Perceptual Masking,
pubmed-meshheading:17723284-Refractory Period, Electrophysiological,
pubmed-meshheading:17723284-Time Factors
|
|
pubmed:year |
2007
|
|
pubmed:articleTitle |
Acoustic-electric interactions in the guinea pig auditory nerve: simultaneous and forward masking of the electrically evoked compound action potential.
|
|
pubmed:affiliation |
Department of Otolaryngology--Head and Neck Surgery, The University of Iowa, Iowa City, IA 52242, USA. kirill-nourski@uiowa.edu
|
|
pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
|
