Source:http://linkedlifedata.com/resource/pubmed/id/17721921
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
2007-11-1
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| pubmed:abstractText |
Pancreatic cancer is one of the most aggressive malignant diseases. We recently reported that N-cadherin plays a key role in tumor progression and metastasis in pancreatic cancer. For this study, we sought to determine if an N-cadherin-blocking peptide (ADH-1) could prevent N-cadherin-mediated tumor progression in a mouse model for pancreatic cancer. The effect of ADH-1 on N-cadherin-mediated cell scattering and migration on collagen I was examined using pancreatic cancer cells. We also examined the influence of ADH-1 on cell apoptosis. Furthermore, in vivo animal studies were performed using orthotopic injection of N-cadherin overexpressing BxPC-3 cells with or without ADH-1 treatment. BxPC-3 and Capan-1 cells exhibited increased expression of N-cadherin in response to collagen I. This increase in N-cadherin promoted cell scattering and migration in response to collagen I. ADH-1 prevented these changes, but did not inhibit upregulation of N-cadherin. TUNEL assays and immunoblots for caspase-3 showed that ADH-1 induced apoptosis in a concentration dependent and N-cadherin dependent manner in pancreatic cancer cells. ADH-1 treatment resulted in significant reductions in tumor growth and lung metastasis in a mouse model for pancreatic cancer. The N-cadherin antagonist, ADH-1 has significant antitumor activity against N-cadherin-expressing cells using in vitro assays and in an orthotopic mouse model for pancreatic cancer, raising the possibility that N-cadherin antagonists have therapeutic potential for the treatment of pancreatic cancer in humans.
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/ADH-1 pepide,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/CDH2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Cadherins,
http://linkedlifedata.com/resource/pubmed/chemical/Collagen,
http://linkedlifedata.com/resource/pubmed/chemical/Oligopeptides,
http://linkedlifedata.com/resource/pubmed/chemical/Peptides, Cyclic,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Small Interfering
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| pubmed:status |
MEDLINE
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| pubmed:month |
Jan
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| pubmed:issn |
1097-0215
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| pubmed:author | |
| pubmed:copyrightInfo |
Copyright 2007 Wiley-Liss, Inc.
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| pubmed:issnType |
Electronic
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| pubmed:day |
1
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| pubmed:volume |
122
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
71-7
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| pubmed:meshHeading |
pubmed-meshheading:17721921-Animals,
pubmed-meshheading:17721921-Antigens, CD,
pubmed-meshheading:17721921-Apoptosis,
pubmed-meshheading:17721921-Cadherins,
pubmed-meshheading:17721921-Cell Adhesion,
pubmed-meshheading:17721921-Cell Movement,
pubmed-meshheading:17721921-Collagen,
pubmed-meshheading:17721921-Disease Progression,
pubmed-meshheading:17721921-Electrophoresis, Polyacrylamide Gel,
pubmed-meshheading:17721921-Female,
pubmed-meshheading:17721921-Humans,
pubmed-meshheading:17721921-Immunoblotting,
pubmed-meshheading:17721921-In Situ Nick-End Labeling,
pubmed-meshheading:17721921-Mice,
pubmed-meshheading:17721921-Mice, Nude,
pubmed-meshheading:17721921-Oligopeptides,
pubmed-meshheading:17721921-Pancreatic Neoplasms,
pubmed-meshheading:17721921-Peptides, Cyclic,
pubmed-meshheading:17721921-RNA, Small Interfering,
pubmed-meshheading:17721921-Tumor Cells, Cultured
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| pubmed:year |
2008
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| pubmed:articleTitle |
ADH-1 suppresses N-cadherin-dependent pancreatic cancer progression.
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| pubmed:affiliation |
Department of Oral Biology, University of Nebraska Medical Center, Omaha, NE 68198-7696, USA.
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| pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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