Linked Life Data

17721201

Source:http://linkedlifedata.com/resource/pubmed/id/17721201

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
2007-8-27
pubmed:abstractText
Human herpesvirus-8 (HHV-8) is associated with several distinct lymphoproliferative disorders: primary effusion lymphoma, multicentric Castleman disease (MCD), MCD-associated plasmablastic lymphoma and HHV-8+, Epstein-Barr virus (EBV)+ germinotropic lymphoproliferative disorder. We report the case of a human immunodeficiency virus (HIV)+ male with fever, generalized lymphadenopathy, and splenomegaly. Two peripheral lymph nodes were excised and showed features of MCD and a prominent proliferation of HHV-8+, EBV+, CD20, CD138, MUM1+, lambda dim+, Ig heavy chain plasmablasts and immunoblasts replacing some follicles. Subsequently, a splenectomy and biopsy of retroperitoneal lymph nodes were performed; the retroperitoneal and splenic hilar lymph nodes showed changes similar to those in the peripheral lymph nodes while the markedly enlarged spleen showed replacement of occasional white pulp by the HHV-8+, EBV+ large cells. The histologic features and coinfection by EBV and HHV-8 suggested a diagnosis of HHV-8+ germinotropic lymphoproliferative disorder. However, the occurrence in an HIV+ individual, the background of MCD, the widespread anatomic distribution and the aggressive clinical course tended to exclude germinotropic lymphoproliferative disorder, and to favor multifocal plasmablastic microlymphoma. The patient died shortly after surgery; postmortem examination showed progression to overt lymphoma. The marrow showed extensive hemophagocytosis, consistent with development of a hemophagocytic syndrome. This unique case has clinical features compatible with a MCD-associated plasmablastic lymphoproliferative disorder, with pathologic features intermediate between HHV-8+ plasmablastic microlymphoma, and HHV-8+ germinotropic lymphoproliferative disorder, although in contrast to both of these, in our case, light chain expression was dim and heavy chain was not detected.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0147-5185
pubmed:author
pubmed:issnType
Print
pubmed:volume
31
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1439-45
pubmed:meshHeading
pubmed-meshheading:17721201-Antigens, CD20, pubmed-meshheading:17721201-Bone Marrow Cells, pubmed-meshheading:17721201-Cell Proliferation, pubmed-meshheading:17721201-Diagnosis, Differential, pubmed-meshheading:17721201-Disease Progression, pubmed-meshheading:17721201-Fatal Outcome, pubmed-meshheading:17721201-Giant Lymph Node Hyperplasia, pubmed-meshheading:17721201-HIV Seropositivity, pubmed-meshheading:17721201-Herpesvirus 4, Human, pubmed-meshheading:17721201-Herpesvirus 8, Human, pubmed-meshheading:17721201-Humans, pubmed-meshheading:17721201-Interferon Regulatory Factors, pubmed-meshheading:17721201-Ki-67 Antigen, pubmed-meshheading:17721201-Lymph Nodes, pubmed-meshheading:17721201-Lymphohistiocytosis, Hemophagocytic, pubmed-meshheading:17721201-Lymphoma, pubmed-meshheading:17721201-Lymphoproliferative Disorders, pubmed-meshheading:17721201-Male, pubmed-meshheading:17721201-Middle Aged, pubmed-meshheading:17721201-Receptors, Complement 3d, pubmed-meshheading:17721201-Splenomegaly, pubmed-meshheading:17721201-Syndecan-1
pubmed:year
2007
pubmed:articleTitle
HHV-8+, EBV+ multicentric plasmablastic microlymphoma in an HIV+ Man: the spectrum of HHV-8+ lymphoproliferative disorders expands.
pubmed:affiliation
*The James Homer Wright Pathology Laboratories of the Massachusetts General Hospital, Boston, MA 02114, USA.
pubmed:publicationType
Journal Article, Case Reports