Source:http://linkedlifedata.com/resource/pubmed/id/17720862
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
9
|
| pubmed:dateCreated |
2007-8-27
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| pubmed:abstractText |
Inorganic polyphosphates [Poly(P)] are often distributed in osteoblasts. We undertook the present study to verify the hypothesis that Poly(P) stimulates osteoblasts and facilitates bone formation. The osteoblast-like cell line MC 3T3-E1 was cultured with Poly(P), and gene expression and potential mineralization were evaluated by reverse-transcription polymerase chain-reaction. Alkaline phosphatase activity, von Kossa staining, and resorption pit formation analyses were also determined. The potential role of Poly(P) in bone formation was assessed in a rat alveolar bone regeneration model. Poly(P) induced osteopontin, osteocalcin, collagen 1alpha, and osteoprotegerin expression and increased alkaline phosphatase activity in MC 3T3-E1 cells. Dentin slice pit formation decreased with mouse osteoblast and bone marrow macrophage co-cultivation in the presence of Poly(P). Promotion of alveolar bone regeneration was observed locally in Poly(P)-treated rats. These findings suggest that Poly(P) plays a role in osteoblastic differentiation, activation, and bone mineralization. Thus, local poly(P) delivery may have a therapeutic benefit in periodontal disease.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
D
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Collagen Type I,
http://linkedlifedata.com/resource/pubmed/chemical/Osteocalcin,
http://linkedlifedata.com/resource/pubmed/chemical/Osteopontin,
http://linkedlifedata.com/resource/pubmed/chemical/Osteoprotegerin,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphates,
http://linkedlifedata.com/resource/pubmed/chemical/Polyphosphates
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| pubmed:status |
MEDLINE
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| pubmed:month |
Sep
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| pubmed:issn |
0022-0345
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
86
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
893-7
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| pubmed:meshHeading |
pubmed-meshheading:17720862-3T3 Cells,
pubmed-meshheading:17720862-Alveolar Bone Loss,
pubmed-meshheading:17720862-Animals,
pubmed-meshheading:17720862-Bone Regeneration,
pubmed-meshheading:17720862-Cell Differentiation,
pubmed-meshheading:17720862-Coculture Techniques,
pubmed-meshheading:17720862-Collagen Type I,
pubmed-meshheading:17720862-Macrophages,
pubmed-meshheading:17720862-Male,
pubmed-meshheading:17720862-Mice,
pubmed-meshheading:17720862-Osteoblasts,
pubmed-meshheading:17720862-Osteocalcin,
pubmed-meshheading:17720862-Osteoclasts,
pubmed-meshheading:17720862-Osteogenesis,
pubmed-meshheading:17720862-Osteopontin,
pubmed-meshheading:17720862-Osteoprotegerin,
pubmed-meshheading:17720862-Phosphates,
pubmed-meshheading:17720862-Polyphosphates,
pubmed-meshheading:17720862-Rats,
pubmed-meshheading:17720862-Rats, Wistar
|
| pubmed:year |
2007
|
| pubmed:articleTitle |
Inorganic polyphosphate: a possible stimulant of bone formation.
|
| pubmed:affiliation |
Department of Oral and Maxillofacial Surgery, Matsumoto Dental University School of Dentistry, Nagano, Japan.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|