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pubmed-article:17720112pubmed:abstractTextMagnesium sulfate (MgSO(4)) is well known as an antagonist of N-methyl-d-aspartate receptors and was used for intrathecal analgesia a century ago. However, the effects of MgSO(4) combined with local anesthetics (LAs) on peripheral nerves are unclear. We tested the hypothesis that MgSO(4) could be used as an adjuvant to prolong and intensify conduction block by amide-type LAs in a rat sciatic-nerve block model. Further, the mechanism of possible synergy between LAs and MgSO(4) was investigated in whole-cell mode patch-clamp experiments.lld:pubmed
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pubmed-article:17720112pubmed:authorpubmed-author:WangGing...lld:pubmed
pubmed-article:17720112pubmed:authorpubmed-author:HungYu-ChunYClld:pubmed
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pubmed-article:17720112pubmed:articleTitleMagnesium sulfate diminishes the effects of amide local anesthetics in rat sciatic-nerve block.lld:pubmed
pubmed-article:17720112pubmed:affiliationDepartment of Anesthesiology, Mackay Memorial Hospital, Taipei, Taiwan.lld:pubmed
pubmed-article:17720112pubmed:publicationTypeJournal Articlelld:pubmed
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