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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2007-8-27
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pubmed:abstractText |
Magnesium sulfate (MgSO(4)) is well known as an antagonist of N-methyl-d-aspartate receptors and was used for intrathecal analgesia a century ago. However, the effects of MgSO(4) combined with local anesthetics (LAs) on peripheral nerves are unclear. We tested the hypothesis that MgSO(4) could be used as an adjuvant to prolong and intensify conduction block by amide-type LAs in a rat sciatic-nerve block model. Further, the mechanism of possible synergy between LAs and MgSO(4) was investigated in whole-cell mode patch-clamp experiments.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17720112-10364859,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17720112-11989501,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17720112-12139537,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17720112-12237201,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17720112-12855352,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17720112-14709478,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17720112-15157705,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17720112-15275796,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17720112-15564952,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17720112-15781543,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17720112-16306739,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17720112-16418019,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17720112-1660396,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17720112-1828878,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17720112-2301766,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17720112-238230,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17720112-2551998,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17720112-6325946,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17720112-6335243,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17720112-6606998,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17720112-8758153,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17720112-8880740,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17720112-9124662
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1098-7339
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
32
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
288-95
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:17720112-Amides,
pubmed-meshheading:17720112-Anesthetics, Local,
pubmed-meshheading:17720112-Animals,
pubmed-meshheading:17720112-Bupivacaine,
pubmed-meshheading:17720112-Dose-Response Relationship, Drug,
pubmed-meshheading:17720112-Lidocaine,
pubmed-meshheading:17720112-Magnesium Sulfate,
pubmed-meshheading:17720112-Motor Activity,
pubmed-meshheading:17720112-Nerve Block,
pubmed-meshheading:17720112-Pain Measurement,
pubmed-meshheading:17720112-Proprioception,
pubmed-meshheading:17720112-Rats,
pubmed-meshheading:17720112-Rats, Sprague-Dawley,
pubmed-meshheading:17720112-Sciatic Nerve,
pubmed-meshheading:17720112-Sodium Channels
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pubmed:articleTitle |
Magnesium sulfate diminishes the effects of amide local anesthetics in rat sciatic-nerve block.
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pubmed:affiliation |
Department of Anesthesiology, Mackay Memorial Hospital, Taipei, Taiwan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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