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rdf:type |
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lifeskim:mentions |
umls-concept:C0003234,
umls-concept:C0017262,
umls-concept:C0018801,
umls-concept:C0034802,
umls-concept:C0086418,
umls-concept:C0087111,
umls-concept:C0185117,
umls-concept:C0441712,
umls-concept:C0876994,
umls-concept:C1522564,
umls-concept:C2911684
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pubmed:issue |
14
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pubmed:dateCreated |
2007-9-17
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pubmed:abstractText |
Trastuzumab can induce cardiotoxicity, particularly when combined with anthracyclines. Myocardial human epidermal growth factor receptor 2 (HER2) expression may be transiently upregulated by a compensatory mechanism following cardiac stress. 111In-DTPA-trastuzumab, scintigraphy can detect HER2 positive tumour lesions, however previously, we found myocardial uptake in only 1 of the 15 anthracycline-pre-treated patients with a median of 11 months after the last anthracycline administration. To evaluate whether myocardial HER2 expression is upregulated by anthracycline-induced cardiac stress or in case of heart failure by chronic pressure or volume overload, we performed 111In-DTPA-trastuzumab scans in patients shortly after anthracyclines and with non-anthracycline-related heart failure.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Anthracyclines,
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal, Humanized,
http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Pentetic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, erbB-2,
http://linkedlifedata.com/resource/pubmed/chemical/trastuzumab
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0959-8049
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pubmed:author |
pubmed-author:GietemaJ AJA,
pubmed-author:JagerP LPL,
pubmed-author:Lub-de HoogeM NMN,
pubmed-author:PerikP JPJ,
pubmed-author:SleijferD TDT,
pubmed-author:SluiterW JWJ,
pubmed-author:SuterT MTM,
pubmed-author:de KorteM AMA,
pubmed-author:de VriesE G EEG,
pubmed-author:van VeldhuisenD JDJ,
pubmed-author:van der GraafW T AWT
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pubmed:issnType |
Print
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pubmed:volume |
43
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2046-51
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:17719768-Adult,
pubmed-meshheading:17719768-Aged,
pubmed-meshheading:17719768-Anthracyclines,
pubmed-meshheading:17719768-Antibodies, Monoclonal,
pubmed-meshheading:17719768-Antibodies, Monoclonal, Humanized,
pubmed-meshheading:17719768-Antineoplastic Agents,
pubmed-meshheading:17719768-Chronic Disease,
pubmed-meshheading:17719768-Female,
pubmed-meshheading:17719768-Heart Diseases,
pubmed-meshheading:17719768-Heart Failure,
pubmed-meshheading:17719768-Humans,
pubmed-meshheading:17719768-Male,
pubmed-meshheading:17719768-Middle Aged,
pubmed-meshheading:17719768-Myocardium,
pubmed-meshheading:17719768-Neoplasms,
pubmed-meshheading:17719768-Pentetic Acid,
pubmed-meshheading:17719768-Receptor, erbB-2,
pubmed-meshheading:17719768-Stress, Physiological,
pubmed-meshheading:17719768-Tomography, Emission-Computed, Single-Photon,
pubmed-meshheading:17719768-Up-Regulation
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pubmed:year |
2007
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pubmed:articleTitle |
111Indium-trastuzumab visualises myocardial human epidermal growth factor receptor 2 expression shortly after anthracycline treatment but not during heart failure: a clue to uncover the mechanisms of trastuzumab-related cardiotoxicity.
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pubmed:affiliation |
Department of Medical Oncology, University of Groningen and University Medical Centre Groningen, PO Box 30.001, 9700 RB Groningen, The Netherlands.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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