Source:http://linkedlifedata.com/resource/pubmed/id/17717631
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
10
|
| pubmed:dateCreated |
2007-10-1
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| pubmed:abstractText |
Drinking water and dietary sources of nitrate and nitrite can react in vivo with amines and amides to form N-nitroso compounds (NOC), potent animal carcinogens. Nitrate is a widespread contaminant of drinking water supplies especially in agricultural areas. We conducted a population-based case-control study of renal cell carcinoma in 1986-1989 in Iowa, a state with elevated levels in many public water supplies. We collected a lifetime water source history, but due to limited monitoring data, most analyses focused on the subpopulation, who used Iowa public supplies with nitrate measurements (actual or imputed data) for > or = 70% of their person-years since 1960 (201 cases, 1,244 controls). We computed the average nitrate level and years using a public supply with nitrate levels >5 and >10 mg/l. Dietary nitrate and nitrite were estimated from a 55-item food frequency questionnaire. There was no association of renal cell carcinoma with the average nitrate level and years using public supplies >5 and >10 mg/l nitrate-nitrogen (10+ years >5 mg/l odds ratio (OR) = 1.03, 95% confidence interval (CI) 0.66, 1.60). However, higher nitrate exposure was associated with an increased risk among subgroups with above the median red meat intake (10+ years >5 mg/l OR = 1.91, 95% CI 1.04-3.51) or below the median vitamin C intake (10+ years >5 mg/l OR = 1.90, 95% CI 1.01, 3.56), dietary factors that increase the endogenous formation of NOC. Exclusion of long-term Des Moines residents, a large proportion of the high exposure categories, attenuated the association. These findings deserve additional study in populations with high water nitrate intake and information on dietary intakes.
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Amines,
http://linkedlifedata.com/resource/pubmed/chemical/Nitrates,
http://linkedlifedata.com/resource/pubmed/chemical/Nitroso Compounds,
http://linkedlifedata.com/resource/pubmed/chemical/Water,
http://linkedlifedata.com/resource/pubmed/chemical/Water Pollutants, Chemical
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| pubmed:status |
MEDLINE
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| pubmed:month |
Dec
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| pubmed:issn |
0957-5243
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
18
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
1141-51
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| pubmed:meshHeading |
pubmed-meshheading:17717631-Adult,
pubmed-meshheading:17717631-Aged,
pubmed-meshheading:17717631-Aged, 80 and over,
pubmed-meshheading:17717631-Amines,
pubmed-meshheading:17717631-Carcinoma, Renal Cell,
pubmed-meshheading:17717631-Female,
pubmed-meshheading:17717631-Food Contamination,
pubmed-meshheading:17717631-Humans,
pubmed-meshheading:17717631-Iowa,
pubmed-meshheading:17717631-Kidney Neoplasms,
pubmed-meshheading:17717631-Male,
pubmed-meshheading:17717631-Middle Aged,
pubmed-meshheading:17717631-Nitrates,
pubmed-meshheading:17717631-Nitroso Compounds,
pubmed-meshheading:17717631-Retrospective Studies,
pubmed-meshheading:17717631-Risk Factors,
pubmed-meshheading:17717631-SEER Program,
pubmed-meshheading:17717631-Water,
pubmed-meshheading:17717631-Water Pollutants, Chemical,
pubmed-meshheading:17717631-Water Supply
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| pubmed:year |
2007
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| pubmed:articleTitle |
Nitrate in public water supplies and the risk of renal cell carcinoma.
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| pubmed:affiliation |
Division of Cancer Epidemiology and Genetics, Occupational and Environmental Epidemiology Branch, National Cancer Institute, NIH/DHHS, Bethesda, MD 20892, USA. wardm@mail.nih.gov
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| pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural,
Research Support, N.I.H., Intramural
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