17717222

Source:http://linkedlifedata.com/resource/pubmed/id/17717222

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0001002, umls-concept:C0002932, umls-concept:C0022631, umls-concept:C0047456, umls-concept:C0871161
pubmed:issue	3
pubmed:dateCreated	2007-8-24
pubmed:abstractText	We tested the hypothesis that two metabolites that are elevated in ketosis (beta-hydroxybutyric acid, and acetone) modulate ion channels in a manner similar to anesthetics and produce anesthesia in animals.
pubmed:grant	http://linkedlifedata.com/resource/pubmed/grant/R01 GM069379
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/1310650
pubmed:citationSubset	AIM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/3-Hydroxybutyric Acid, http://linkedlifedata.com/resource/pubmed/chemical/Acetone, http://linkedlifedata.com/resource/pubmed/chemical/Anesthetics, http://linkedlifedata.com/resource/pubmed/chemical/GABRA1 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/GABRG2 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Gabra1 protein, rat, http://linkedlifedata.com/resource/pubmed/chemical/Gabrb2 protein, rat, http://linkedlifedata.com/resource/pubmed/chemical/Gabrg2 protein, rat, http://linkedlifedata.com/resource/pubmed/chemical/Ion Channels, http://linkedlifedata.com/resource/pubmed/chemical/Ketone Bodies, http://linkedlifedata.com/resource/pubmed/chemical/NR1 NMDA receptor, http://linkedlifedata.com/resource/pubmed/chemical/NR2A NMDA receptor, http://linkedlifedata.com/resource/pubmed/chemical/Potassium Channels, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, GABA-A, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Glycine, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, N-Methyl-D-Aspartate, http://linkedlifedata.com/resource/pubmed/chemical/glycine receptor alpha1
pubmed:status	MEDLINE
pubmed:month	Sep
pubmed:issn	1526-7598
pubmed:author	pubmed-author:BrosnanRobert JRJ, pubmed-author:EgerEdmond IEI2nd, pubmed-author:MilutinovicPavle SPS, pubmed-author:SonnerJames MJM, pubmed-author:YangLiyaL, pubmed-author:ZhaoJingJ
pubmed:issnType	Electronic
pubmed:volume	105
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	673-9
pubmed:dateRevised	2010-11-18
pubmed:meshHeading	pubmed-meshheading:17717222-3-Hydroxybutyric Acid, pubmed-meshheading:17717222-Acetone, pubmed-meshheading:17717222-Anesthetics, pubmed-meshheading:17717222-Animals, pubmed-meshheading:17717222-Diabetic Ketoacidosis, pubmed-meshheading:17717222-Dose-Response Relationship, Drug, pubmed-meshheading:17717222-Humans, pubmed-meshheading:17717222-Ion Channels, pubmed-meshheading:17717222-Ketone Bodies, pubmed-meshheading:17717222-Larva, pubmed-meshheading:17717222-Membrane Potentials, pubmed-meshheading:17717222-Microinjections, pubmed-meshheading:17717222-Movement, pubmed-meshheading:17717222-Oocytes, pubmed-meshheading:17717222-Patch-Clamp Techniques, pubmed-meshheading:17717222-Potassium Channels, pubmed-meshheading:17717222-Rats, pubmed-meshheading:17717222-Receptors, GABA-A, pubmed-meshheading:17717222-Receptors, Glycine, pubmed-meshheading:17717222-Receptors, N-Methyl-D-Aspartate, pubmed-meshheading:17717222-Xenopus laevis
pubmed:year	2007
pubmed:articleTitle	Anesthetic properties of the ketone bodies beta-hydroxybutyric acid and acetone.
pubmed:affiliation	Department of Anesthesia and Perioperative Care, University of California, San Francisco, California 94143-0464, USA.
pubmed:publicationType	Journal Article, Research Support, N.I.H., Extramural