|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0005953,
umls-concept:C0008018,
umls-concept:C0014467,
umls-concept:C0030685,
umls-concept:C0085416,
umls-concept:C0205314,
umls-concept:C0231491,
umls-concept:C0391871,
umls-concept:C0679622,
umls-concept:C0680255,
umls-concept:C1283071,
umls-concept:C1415238,
umls-concept:C1533157,
umls-concept:C1963578
|
|
pubmed:issue |
12
|
|
pubmed:dateCreated |
2007-11-6
|
|
pubmed:abstractText |
Chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2) has been revealed to be a novel receptor for prostaglandin (PG) D(2), which is a major mast cell product released during the allergic response. The aim of this study was to analyze the effects of a newly developed small molecule antagonist of CRTH2, Cay10471, on eosinophil function with respect to recruitment, respiratory burst and degranulation.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Dec
|
|
pubmed:issn |
0105-4538
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
62
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1401-9
|
|
pubmed:dateRevised |
2011-4-6
|
|
pubmed:meshHeading |
pubmed-meshheading:17714552-Animals,
pubmed-meshheading:17714552-Bone Marrow,
pubmed-meshheading:17714552-Carbazoles,
pubmed-meshheading:17714552-Cell Degranulation,
pubmed-meshheading:17714552-Cells, Cultured,
pubmed-meshheading:17714552-Chemotaxis, Leukocyte,
pubmed-meshheading:17714552-Eosinophils,
pubmed-meshheading:17714552-Female,
pubmed-meshheading:17714552-Guinea Pigs,
pubmed-meshheading:17714552-Humans,
pubmed-meshheading:17714552-Male,
pubmed-meshheading:17714552-Receptors, Immunologic,
pubmed-meshheading:17714552-Receptors, Prostaglandin,
pubmed-meshheading:17714552-Respiratory Burst,
pubmed-meshheading:17714552-Sulfonamides,
pubmed-meshheading:17714552-Th2 Cells
|
|
pubmed:year |
2007
|
|
pubmed:articleTitle |
A novel antagonist of CRTH2 blocks eosinophil release from bone marrow, chemotaxis and respiratory burst.
|
|
pubmed:affiliation |
Institute of Experimental and Clinical Pharmacology, Medical University of Graz, Graz, Austria.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
