Linked Life Data

1771397

Source:http://linkedlifedata.com/resource/pubmed/id/1771397

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1992-2-21
pubmed:abstractText
The right knee joint of 11 rabbits was immobilized in full extension with a splint for a period of three days. The effect of the immobilization and subsequent remobilization on plasma hyaluronan (HA) level was measured, using a sensitive radiometric HA binding protein (125I-HABP) assay. No significant effect of the immobilization on plasma HA level (54 +/- 4 micrograms/l) was noted, but shortly (45 minutes) after splint removal, plasma hyaluronate was at its highest (91 +/- 20 micrograms/l). One day after removal of the splint a return to baseline (53 +/- 6 micrograms/l) was observed. It is suggested that HA may accumulate in the joint during immobilization. Shortly after removing the splint, the level of HA shows a rise in many of the rabbits, even if this is not a consistent finding, probably due to variation in the extent and kinetics of the HA mobilization. Such an accumulation of HA could be deleterious for joint tissues, since HA is an-effective stimulator of interleukin-1 (also called catabolin) synthesis and secretion, and since immobilization osteoarthritis ensues in the splinted rabbit joints.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0300-9742
pubmed:author
pubmed:issnType
Print
pubmed:volume
20
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
392-6
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
Plasma hyaluronan levels in rabbit immobilization osteoarthritis: effect of remobilization.
pubmed:affiliation
Fourth Department of Medicine, Helsinki University Central Hospital, Finland.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't