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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2007-8-21
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pubmed:abstractText |
A pilot candidate gene association study was conducted to investigate the role of three common functional genetic polymorphisms of the low-affinity Fc gamma receptors, FCGR2A (131H/R), FCGR3A (158F/V) and FCGR3B (NA1/NA2) in Cryptococcus neoformans infections in individuals not infected with HIV. The FCGR2A 131RR and FCGR3A 158VV genotypes were over-represented [OR: 1.67 (1.05-2.63) and 2.04 (1.06-4.00), respectively] whereas the FCGR3B NA2NA2 was under-represented in patients with cryptococcosis (28% vs. 40% in controls). An analysis of haplotypes showed a significant difference in distribution between cases and controls overall and in Caucasians.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/FCGR2A protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/FCGR3A protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/FCGR3B protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/GPI-Linked Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, IgG
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1369-3786
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
45
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
513-8
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:17710620-Antigens, CD,
pubmed-meshheading:17710620-Case-Control Studies,
pubmed-meshheading:17710620-Cryptococcosis,
pubmed-meshheading:17710620-Cryptococcus neoformans,
pubmed-meshheading:17710620-European Continental Ancestry Group,
pubmed-meshheading:17710620-Female,
pubmed-meshheading:17710620-GPI-Linked Proteins,
pubmed-meshheading:17710620-Genetic Predisposition to Disease,
pubmed-meshheading:17710620-Genotype,
pubmed-meshheading:17710620-HIV Seronegativity,
pubmed-meshheading:17710620-Haplotypes,
pubmed-meshheading:17710620-Humans,
pubmed-meshheading:17710620-Male,
pubmed-meshheading:17710620-Middle Aged,
pubmed-meshheading:17710620-Pilot Projects,
pubmed-meshheading:17710620-Polymorphism, Genetic,
pubmed-meshheading:17710620-Receptors, IgG,
pubmed-meshheading:17710620-Risk Factors
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pubmed:year |
2007
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pubmed:articleTitle |
Study of common functional genetic polymorphisms of FCGR2A, 3A and 3B genes and the risk for cryptococcosis in HIV-uninfected patients.
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pubmed:affiliation |
National Cancer Institute, Bethesda, MD, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Intramural
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