|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
10
|
|
pubmed:dateCreated |
2007-9-4
|
|
pubmed:abstractText |
High-density lipoprotein cholesterol (HDL) levels are a major risk factor for cardiovascular disease. Previously we identified a quantitative trait locus on baboon chromosome 18 that regulates HDL. From positional cloning studies and expression studies, we identified the endothelial lipase gene (LIPG) as the primary candidate gene for the quantitative trait locus. The mechanism by which LIPG variation influences HDL levels has not been determined.
|
|
pubmed:grant |
|
|
pubmed:commentsCorrections |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
AIM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Sep
|
|
pubmed:issn |
1524-4539
|
|
pubmed:author |
|
|
pubmed:issnType |
Electronic
|
|
pubmed:day |
4
|
|
pubmed:volume |
116
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1185-95
|
|
pubmed:dateRevised |
2008-11-21
|
|
pubmed:meshHeading |
pubmed-meshheading:17709635-Amino Acid Sequence,
pubmed-meshheading:17709635-Animals,
pubmed-meshheading:17709635-Cholesterol, HDL,
pubmed-meshheading:17709635-Endothelium, Vascular,
pubmed-meshheading:17709635-Genetic Variation,
pubmed-meshheading:17709635-Humans,
pubmed-meshheading:17709635-Lipase,
pubmed-meshheading:17709635-Molecular Sequence Data,
pubmed-meshheading:17709635-Papio,
pubmed-meshheading:17709635-Polymorphism, Genetic,
pubmed-meshheading:17709635-Promoter Regions, Genetic
|
|
pubmed:year |
2007
|
|
pubmed:articleTitle |
Identification of promoter variants in baboon endothelial lipase that regulate high-density lipoprotein cholesterol levels.
|
|
pubmed:affiliation |
Department of Genetics, Southwest National Primate Research Center, Southwest Foundation for Biomedical Research, 7620 NW Loop 410, San Antonio, TX 78227, USA. lcox@darwin.sfbr.org.
|
|
pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, N.I.H., Extramural
|
